| http://purl.uniprot.org/citations/31577946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31577946 | http://www.w3.org/2000/01/rdf-schema#comment | "Type I interferons (IFNs) play important roles in antitumor immunity. We generated IFN-α-producing cells by genetically engineered induced pluripotent stem cell (iPSC)-derived proliferating myeloid cells (iPSC-pMCs). Local administration of IFN-α-producing iPSC-pMCs (IFN-α-iPSC-pMCs) alters the tumor microenvironment and propagates the molecular signature associated with type I IFN. The gene-modified cell actively influences host XCR1+ dendritic cells to enhance CD8+ T cell priming, resulting in CXCR3-dependent and STING-IRF3 pathway-independent systemic tumor control. Administration of IFN-α-iPSC-pMCs in combination with immune checkpoint blockade overcomes resistance to single-treatment modalities and generates long-lasting antitumor immunity. These preclinical data suggest that IFN-α-iPSC-pMCs might constitute effective immune-stimulating agents for cancer that are refractory to checkpoint blockade."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2019.08.086"xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Cheng Z."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Nishimura Y."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Miyashita A."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Okada S."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Sasaki Y."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Sawada Y."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Kubo Y."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Endo I."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Kaisho T."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Kaneko S."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Tatsumi M."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Uemura Y."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Ueda N."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Fukushima S."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Ihn H."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Takubo K."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Nakatsura T."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Senju S."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Iwama T."xsd:string |
| http://purl.uniprot.org/citations/31577946 | http://purl.uniprot.org/core/author | "Tsuchiya N."xsd:string |