| http://purl.uniprot.org/citations/31578241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31578241 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor receptor 2 (TNFR2) is the alternate receptor for TNF and can mediate both pro- and anti-inflammatory activities of T cells. Although TNFR2 has been linked to enhanced suppressive activity of regulatory T cells (Tregs) in autoimmune diseases, the viability of TNFR2 as a target for cancer immunotherapy has been underappreciated. Here, we show that new murine monoclonal anti-TNFR2 antibodies yield robust antitumor activity and durable protective memory in multiple mouse cancer cell line models. The antibodies mediate potent Fc-dependent T cell costimulation and do not result in significant depletion of Tregs Corresponding human agonistic monoclonal anti-TNFR2 antibodies were identified and also had antitumor effects in humanized mouse models. Anti-TNFR2 antibodies could be developed as a novel treatment option for patients with cancer."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.org/dc/terms/identifier | "doi:10.1126/scitranslmed.aax0720"xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Kumar S."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Jiao Y."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Qiu J."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Paragas V."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Wong C."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Zhang K."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Marks J.D."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Richards J."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Muda M."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Qiao W."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Croft M."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Suchy J."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Craig G."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Lulo J."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Feau S."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Grabow S."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Kohli N."xsd:string |
| http://purl.uniprot.org/citations/31578241 | http://purl.uniprot.org/core/author | "Jakubowski A."xsd:string |