| http://purl.uniprot.org/citations/31578820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31578820 | http://www.w3.org/2000/01/rdf-schema#comment | "SARI (suppressor of AP-1, regulated by IFN) impaired tumour growth by promoting apoptosis and inhibiting cell proliferation and tumour angiogenesis in various cancers. However, the role of SARI in regulating tumour-associated inflammation microenvironment is still elusive. In our study, the colitis-dependent and -independent primary model were established in SARI deficiency mice and immuno-reconstructive mice to investigate the functional role of SARI in regulating tumour-associated inflammation microenvironment and primary colon cancer formation. The results have shown that SARI deficiency promotes colitis-associated cancer (CAC) development only in the presence of colon inflammation. SARI inhibited tumour-associated macrophages (TAM) infiltration in colon tissues, and SARI deficiency in bone marrow cells has no observed role in the promotion of intestinal tumorigenesis. Mechanism investigations indicated that SARI down-regulates p-STAT1 and STAT1 expression in colon cancer cells, following inhibition of MCP-1/CCR2 axis activation during CAC development. Inverse correlations between SARI expression and macrophage infiltration, MCP-1 expression and p-STAT1 expression were also demonstrated in colon malignant tissues. Collectively, our results prove the inhibition role of SARI in colon cancer formation through regulating TAM infiltration."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.org/dc/terms/identifier | "doi:10.1111/jcmm.14699"xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Chen N."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Cheng L."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Dong Z."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Dai L."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Huang W."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Lin Y."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Zhou Z."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Yu D."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Deng H."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Yin Y."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Su X."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Fang C."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Fan P."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/author | "Shi G."xsd:string |
| http://purl.uniprot.org/citations/31578820 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |