| http://purl.uniprot.org/citations/31582721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31582721 | http://www.w3.org/2000/01/rdf-schema#comment | "LRRC7 has been identified as a candidate gene for severe childhood emotional dysregulation. Direct experimental evidence for a role of LRRC7 in the disease is needed, as is a better understanding of its impact on neuronal structure and signaling, and hence potential treatment targets. Here, we generated and analyzed an Lrrc7 mutant mouse line. Consistent with a critical role of LRRC7 in emotional regulation, mutant mice had inappropriate juvenile aggressive behavior and significant anxiety-like behavior and social dysfunction in adulthood. The pivotal role of mGluR5 signaling was demonstrated by rescue of behavioral defects with augmentation of mGluR5 receptor activity by 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB). Intra-peritoneal injection of CDPPB alleviated abnormal juvenile behavior, as well as anxiety-like behavior and hypersociability at adulthood. Furthermore, mutant primary neurons had impaired neurite outgrowth which was rescued by CDPPB treatment. In conclusion, Lrrc7 mutant mice provide a valuable tool to model childhood emotional dysregulation and persistent mental health comorbidities. Moreover, our data highlight an important role of LRRC7 in mGluR5 signaling, which is a potential new treatment target for anxiety and social dysfunction."xsd:string |
| http://purl.uniprot.org/citations/31582721 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41398-019-0580-9"xsd:string |
| http://purl.uniprot.org/citations/31582721 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/31582721 | http://purl.uniprot.org/core/author | "Chan S.Y."xsd:string |
| http://purl.uniprot.org/citations/31582721 | http://purl.uniprot.org/core/author | "Chan A.K.W."xsd:string |
| http://purl.uniprot.org/citations/31582721 | http://purl.uniprot.org/core/author | "McAlonan G."xsd:string |
| http://purl.uniprot.org/citations/31582721 | http://purl.uniprot.org/core/author | "Chong C.H."xsd:string |
| http://purl.uniprot.org/citations/31582721 | http://purl.uniprot.org/core/author | "Mak P.H.S."xsd:string |
| http://purl.uniprot.org/citations/31582721 | http://purl.uniprot.org/core/author | "Leung E.H.W."xsd:string |
| http://purl.uniprot.org/citations/31582721 | http://purl.uniprot.org/core/author | "Ng C.C.P."xsd:string |
| http://purl.uniprot.org/citations/31582721 | http://purl.uniprot.org/core/author | "Tan V.H."xsd:string |
| http://purl.uniprot.org/citations/31582721 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31582721 | http://purl.uniprot.org/core/name | "Transl Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/31582721 | http://purl.uniprot.org/core/pages | "244"xsd:string |
| http://purl.uniprot.org/citations/31582721 | http://purl.uniprot.org/core/title | "Lrrc7 mutant mice model developmental emotional dysregulation that can be alleviated by mGluR5 allosteric modulation."xsd:string |
| http://purl.uniprot.org/citations/31582721 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/31582721 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31582721 |
| http://purl.uniprot.org/citations/31582721 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31582721 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDT9-mappedCitation-31582721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31582721 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFZ5-mappedCitation-31582721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31582721 |
| http://purl.uniprot.org/uniprot/#_E9Q6L9-mappedCitation-31582721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31582721 |
| http://purl.uniprot.org/uniprot/#_A0A571BEA5-mappedCitation-31582721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31582721 |
| http://purl.uniprot.org/uniprot/#_B2BH30-mappedCitation-31582721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31582721 |
| http://purl.uniprot.org/uniprot/#_E9QMC2-mappedCitation-31582721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31582721 |