| http://purl.uniprot.org/citations/31582737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31582737 | http://www.w3.org/2000/01/rdf-schema#comment | "Negative symptoms, such as amotivation and anhedonia, are a major cause of functional impairment in schizophrenia. There are currently no licensed treatments for negative symptoms, highlighting the need to understand the molecular mechanisms underlying them. Mu-opioid receptors (MOR) in the striatum play a key role in hedonic processing and reward function and are reduced post-mortem in schizophrenia. However, it is unknown if mu-opioid receptor availability is altered in-vivo or related to negative symptoms in schizophrenia. Using [11 C]-carfentanil positron emission tomography (PET) scans in 19 schizophrenia patients and 20 age-matched healthy controls, here we show a significantly lower MOR availability in patients with schizophrenia in the striatum (Cohen's d = 0.7), and the hedonic network. In addition, we report a marked global increase in inter-regional covariance of MOR availability in schizophrenia, largely due to increased cortical-subcortical covariance."xsd:string |
| http://purl.uniprot.org/citations/31582737 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-12366-4"xsd:string |
| http://purl.uniprot.org/citations/31582737 | http://purl.uniprot.org/core/author | "Myers J."xsd:string |
| http://purl.uniprot.org/citations/31582737 | http://purl.uniprot.org/core/author | "Rabiner E.A."xsd:string |
| http://purl.uniprot.org/citations/31582737 | http://purl.uniprot.org/core/author | "Howes O.D."xsd:string |
| http://purl.uniprot.org/citations/31582737 | http://purl.uniprot.org/core/author | "Ashok A.H."xsd:string |
| http://purl.uniprot.org/citations/31582737 | http://purl.uniprot.org/core/author | "Reis Marques T."xsd:string |
| http://purl.uniprot.org/citations/31582737 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31582737 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/31582737 | http://purl.uniprot.org/core/pages | "4493"xsd:string |
| http://purl.uniprot.org/citations/31582737 | http://purl.uniprot.org/core/title | "Reduced mu opioid receptor availability in schizophrenia revealed with [11C]-carfentanil positron emission tomographic Imaging."xsd:string |
| http://purl.uniprot.org/citations/31582737 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/31582737 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31582737 |
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| http://purl.uniprot.org/uniprot/#_A0A0F6TN24-mappedCitation-31582737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31582737 |
| http://purl.uniprot.org/uniprot/#_A0A089PQW6-mappedCitation-31582737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31582737 |
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| http://purl.uniprot.org/uniprot/#_A0A0F6TMM4-mappedCitation-31582737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31582737 |
| http://purl.uniprot.org/uniprot/#_A0A0F6TMT4-mappedCitation-31582737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31582737 |
| http://purl.uniprot.org/uniprot/#_A0A0F6RAI2-mappedCitation-31582737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31582737 |
| http://purl.uniprot.org/uniprot/#_A0A0F6RA07-mappedCitation-31582737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31582737 |
| http://purl.uniprot.org/uniprot/#_A0A6H0WCP3-mappedCitation-31582737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31582737 |
| http://purl.uniprot.org/uniprot/#_A0A6H0WF09-mappedCitation-31582737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31582737 |
| http://purl.uniprot.org/uniprot/#_B7SXT0-mappedCitation-31582737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31582737 |