http://purl.uniprot.org/citations/31582853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/31582853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/31582853 | http://www.w3.org/2000/01/rdf-schema#comment | "Clathrin forms diverse lattice and cage structures that change size and shape rapidly in response to the needs of eukaryotic cells during clathrin-mediated endocytosis and intracellular trafficking. We present the cryo-EM structure and molecular model of assembled porcine clathrin, providing insights into interactions that stabilize key elements of the clathrin lattice, namely, between adjacent heavy chains, at the light chain-heavy chain interface and within the trimerization domain. Furthermore, we report cryo-EM maps for five different clathrin cage architectures. Fitting structural models to three of these maps shows that their assembly requires only a limited range of triskelion leg conformations, yet inherent flexibility is required to maintain contacts. Analysis of the protein-protein interfaces shows remarkable conservation of contact sites despite architectural variation. These data reveal a universal mode of clathrin assembly that allows variable cage architecture and adaptation of coated vesicle size and shape during clathrin-mediated vesicular trafficking or endocytosis."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41594-019-0292-0"xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41594-019-0292-0"xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Cheng Y."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Cheng Y."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Smith C.J."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Smith C.J."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Cameron A.D."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Cameron A.D."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Baker M."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Baker M."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Sessions R.B."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Sessions R.B."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Armache J.P."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Armache J.P."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Morris K.L."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Morris K.L."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Jones J.R."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Jones J.R."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Avila Ibarra A."xsd:string |
http://purl.uniprot.org/citations/31582853 | http://purl.uniprot.org/core/author | "Avila Ibarra A."xsd:string |