| http://purl.uniprot.org/citations/31585407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31585407 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt signaling plays a key role in regulating bone remodeling. In vitro studies suggest that sclerostin's inhibitory action on Lrp5 is facilitated by the membrane-associated receptor Lrp4. We generated an Lrp4 R1170W knockin mouse model (Lrp4KI), based on a published mutation in patients with high bone mass (HBM). Lrp4KI mice have an HBM phenotype (assessed radiographically), including increased bone strength and formation. Overexpression of a Sost transgene had osteopenic effects in Lrp4-WT but not Lrp4KI mice. Conversely, sclerostin inhibition had blunted osteoanabolic effects in Lrp4KI mice. In a disuse-induced bone wasting model, Lrp4KI mice exhibit significantly less bone loss than wild-type (WT) mice. In summary, mice harboring the Lrp4-R1170W missense mutation recapitulate the human HBM phenotype, are less sensitive to altered sclerostin levels, and are protected from disuse-induced bone loss. Lrp4 is an attractive target for pharmacological targeting aimed at increasing bone mass and preventing bone loss due to disuse."xsd:string |
| http://purl.uniprot.org/citations/31585407 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2019.09.023"xsd:string |
| http://purl.uniprot.org/citations/31585407 | http://purl.uniprot.org/core/author | "Hoggatt A.M."xsd:string |
| http://purl.uniprot.org/citations/31585407 | http://purl.uniprot.org/core/author | "Pavalko F.M."xsd:string |
| http://purl.uniprot.org/citations/31585407 | http://purl.uniprot.org/core/author | "Bellido T."xsd:string |
| http://purl.uniprot.org/citations/31585407 | http://purl.uniprot.org/core/author | "Loots G.G."xsd:string |
| http://purl.uniprot.org/citations/31585407 | http://purl.uniprot.org/core/author | "Robling A.G."xsd:string |
| http://purl.uniprot.org/citations/31585407 | http://purl.uniprot.org/core/author | "Sato A.Y."xsd:string |
| http://purl.uniprot.org/citations/31585407 | http://purl.uniprot.org/core/author | "Horan D.J."xsd:string |
| http://purl.uniprot.org/citations/31585407 | http://purl.uniprot.org/core/author | "Bullock W.A."xsd:string |
| http://purl.uniprot.org/citations/31585407 | http://purl.uniprot.org/core/author | "Elmendorf A.J."xsd:string |
| http://purl.uniprot.org/citations/31585407 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31585407 | http://purl.uniprot.org/core/name | "iScience"xsd:string |
| http://purl.uniprot.org/citations/31585407 | http://purl.uniprot.org/core/pages | "205-215"xsd:string |
| http://purl.uniprot.org/citations/31585407 | http://purl.uniprot.org/core/title | "Lrp4 Mediates Bone Homeostasis and Mechanotransduction through Interaction with Sclerostin In Vivo."xsd:string |
| http://purl.uniprot.org/citations/31585407 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/31585407 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31585407 |
| http://purl.uniprot.org/citations/31585407 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31585407 |
| http://purl.uniprot.org/uniprot/#_Q8VI56-mappedCitation-31585407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31585407 |
| http://purl.uniprot.org/uniprot/Q8VI56 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31585407 |