| http://purl.uniprot.org/citations/31586599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31586599 | http://www.w3.org/2000/01/rdf-schema#comment | "G-quadruplexes (G4) are secondary structures of nucleic acids that can form in cells and have diverse biological functions. Several biologically important proteins interact with G-quadruplexes, of which RHAU (or DHX36) - a helicase from the DEAH-box superfamily, was shown to bind and unwind G-quadruplexes efficiently. We report a X-ray co-crystal structure at 1.5 Å resolution of an N-terminal fragment of RHAU bound to an exposed tetrad of a parallel-stranded G-quadruplex. The RHAU peptide folds into an L-shaped α-helix, and binds to a G-quadruplex through π-stacking and electrostatic interactions. X-ray crystal structure of our complex identified key amino acid residues important for G-quadruplex-peptide binding interaction at the 3'-end G•G•G•G tetrad. Together with previous solution and crystal structures of RHAU bound to the 5'-end G•G•G•G and G•G•A•T tetrads, our crystal structure highlights the occurrence of a robust G-quadruplex recognition motif within RHAU that can adapt to different accessible tetrads."xsd:string |
| http://purl.uniprot.org/citations/31586599 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jsb.2019.10.001"xsd:string |
| http://purl.uniprot.org/citations/31586599 | http://purl.uniprot.org/core/author | "Mechulam Y."xsd:string |
| http://purl.uniprot.org/citations/31586599 | http://purl.uniprot.org/core/author | "Schmitt E."xsd:string |
| http://purl.uniprot.org/citations/31586599 | http://purl.uniprot.org/core/author | "Cheong V.V."xsd:string |
| http://purl.uniprot.org/citations/31586599 | http://purl.uniprot.org/core/author | "Heddi B."xsd:string |
| http://purl.uniprot.org/citations/31586599 | http://purl.uniprot.org/core/author | "Phan A.T."xsd:string |
| http://purl.uniprot.org/citations/31586599 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31586599 | http://purl.uniprot.org/core/name | "J Struct Biol"xsd:string |
| http://purl.uniprot.org/citations/31586599 | http://purl.uniprot.org/core/pages | "107399"xsd:string |
| http://purl.uniprot.org/citations/31586599 | http://purl.uniprot.org/core/title | "Recognition of different base tetrads by RHAU (DHX36): X-ray crystal structure of the G4 recognition motif bound to the 3'-end tetrad of a DNA G-quadruplex."xsd:string |
| http://purl.uniprot.org/citations/31586599 | http://purl.uniprot.org/core/volume | "209"xsd:string |
| http://purl.uniprot.org/citations/31586599 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31586599 |
| http://purl.uniprot.org/citations/31586599 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31586599 |
| http://purl.uniprot.org/uniprot/#_B7Z8P5-mappedCitation-31586599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31586599 |
| http://purl.uniprot.org/uniprot/#_Q9H2U1-mappedCitation-31586599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31586599 |
| http://purl.uniprot.org/uniprot/Q9H2U1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31586599 |
| http://purl.uniprot.org/uniprot/B7Z8P5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31586599 |