| http://purl.uniprot.org/citations/31591574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31591574 | http://www.w3.org/2000/01/rdf-schema#comment | "The activation of T cells by the T cell antigen receptor (TCR) results in the formation of signaling protein complexes (signalosomes), the composition of which has not been analyzed at a systems level. Here, we isolated primary CD4+ T cells from 15 gene-targeted mice, each expressing one tagged form of a canonical protein of the TCR-signaling pathway. Using affinity purification coupled with mass spectrometry, we analyzed the composition and dynamics of the signalosomes assembling around each of the tagged proteins over 600 s of TCR engagement. We showed that the TCR signal-transduction network comprises at least 277 unique proteins involved in 366 high-confidence interactions, and that TCR signals diversify extensively at the level of the plasma membrane. Integrating the cellular abundance of the interacting proteins and their interaction stoichiometry provided a quantitative and contextual view of each documented interaction, permitting anticipation of whether ablation of a single interacting protein can impinge on the whole TCR signal-transduction network."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41590-019-0489-8"xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Liang Y."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Lu L."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Girard L."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Burlet-Schiltz O."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Gonzalez de Peredo A."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Kersse K."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Fiore F."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Malissen B."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Malissen M."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Roncagalli R."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Chaoui K."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Luche H."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Chaix J."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Goncalves Menoita M."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Voisinne G."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/author | "Ounoughene Y."xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/pages | "1530-1541"xsd:string |
| http://purl.uniprot.org/citations/31591574 | http://purl.uniprot.org/core/title | "Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics."xsd:string |