| http://purl.uniprot.org/citations/31594232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31594232 | http://www.w3.org/2000/01/rdf-schema#comment | "Ubiquitin Specific Protease-13 (USP13) is a de-ubiquinating enzyme that regulates protein ubiquitination and clearance. The role of USP13 is largely unknown in neurodegeneration. In this study we aim to demonstrate whether tau accumulation and/or clearance depends on ubiquitination/de-ubiquitination via USP-13. We used transgenic animal models of human amyloid precursor protein (APP) or P301L tau mutations and genetically knocked-down USP13 expression via shRNA to determine USP13 effects on tau ubiquitination and levels. We found a two-fold increase of USP13 levels in postmortem Alzheimer's disease (AD) brains. USP13 knockdown significantly increased the activity of the 20S proteasome and reduced the levels of hyper-phosphorylated tau (p-tau) in primary cortical neurons. USP13 knockdown also reduced the levels of amyloid and increased p-tau ubiquitination and clearance in transgenic animal models that overexpress murine tau as a result of the expression of familial APP mutations (TgAPP) and the human mutant P301L tau (rTg4510), respectively. Clearance of p-tau appears to be mediated by autophagy in these animal models. Taken together, these data suggest that USP13 knockdown reduces p-tau accumulation via regulation of ubiquitination/de-ubiquitination and mediates its clearance via autophagy and/or the proteasome. These results suggest that USP13 inhibition may be a therapeutic strategy to reduce accumulation of plaques and toxic p-tau in AD and human tauopathies."xsd:string |
| http://purl.uniprot.org/citations/31594232 | http://purl.org/dc/terms/identifier | "doi:10.3233/jad-190635"xsd:string |
| http://purl.uniprot.org/citations/31594232 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/31594232 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/31594232 | http://purl.uniprot.org/core/author | "Shi W."xsd:string |
| http://purl.uniprot.org/citations/31594232 | http://purl.uniprot.org/core/author | "Ferrante D."xsd:string |
| http://purl.uniprot.org/citations/31594232 | http://purl.uniprot.org/core/author | "Hebron M.L."xsd:string |
| http://purl.uniprot.org/citations/31594232 | http://purl.uniprot.org/core/author | "Moussa C."xsd:string |
| http://purl.uniprot.org/citations/31594232 | http://purl.uniprot.org/core/author | "Kurd-Misto B."xsd:string |
| http://purl.uniprot.org/citations/31594232 | http://purl.uniprot.org/core/author | "Lekah E."xsd:string |
| http://purl.uniprot.org/citations/31594232 | http://purl.uniprot.org/core/author | "Mulki S."xsd:string |
| http://purl.uniprot.org/citations/31594232 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31594232 | http://purl.uniprot.org/core/name | "J Alzheimers Dis"xsd:string |
| http://purl.uniprot.org/citations/31594232 | http://purl.uniprot.org/core/pages | "425-441"xsd:string |
| http://purl.uniprot.org/citations/31594232 | http://purl.uniprot.org/core/title | "Ubiquitin Specific Protease 13 Regulates Tau Accumulation and Clearance in Models of Alzheimer's Disease."xsd:string |
| http://purl.uniprot.org/citations/31594232 | http://purl.uniprot.org/core/volume | "72"xsd:string |
| http://purl.uniprot.org/citations/31594232 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31594232 |
| http://purl.uniprot.org/citations/31594232 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31594232 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YZ17-mappedCitation-31594232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31594232 |
| http://purl.uniprot.org/uniprot/#_Q92995-mappedCitation-31594232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31594232 |
| http://purl.uniprot.org/uniprot/Q92995 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31594232 |
| http://purl.uniprot.org/uniprot/A0A0A6YZ17 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31594232 |