| http://purl.uniprot.org/citations/31597093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31597093 | http://www.w3.org/2000/01/rdf-schema#comment | "In Alzheimer's disease (AD), spliceosomal proteins with critical roles in RNA processing aberrantly aggregate and mislocalize to Tau neurofibrillary tangles. We test the hypothesis that Tau-spliceosome interactions disrupt pre-mRNA splicing in AD. In human postmortem brain with AD pathology, Tau coimmunoprecipitates with spliceosomal components. In Drosophila, pan-neuronal Tau expression triggers reductions in multiple core and U1-specific spliceosomal proteins, and genetic disruption of these factors, including SmB, U1-70K, and U1A, enhances Tau-mediated neurodegeneration. We further show that loss of function in SmB, encoding a core spliceosomal protein, causes decreased survival, progressive locomotor impairment, and neuronal loss, independent of Tau toxicity. Lastly, RNA sequencing reveals a similar profile of mRNA splicing errors in SmB mutant and Tau transgenic flies, including intron retention and non-annotated cryptic splice junctions. In human brains, we confirm cryptic splicing errors in association with neurofibrillary tangle burden. Our results implicate spliceosome disruption and the resulting transcriptome perturbation in Tau-mediated neurodegeneration in AD."xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2019.08.104"xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/author | "Hsieh Y.C."xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/author | "Guo C."xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/author | "Lah J.J."xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/author | "Levey A.I."xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/author | "Dammer E.B."xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/author | "De Jager P.L."xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/author | "Bennett D.A."xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/author | "Shulman J.M."xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/author | "Seyfried N.T."xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/author | "Abreha M."xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/author | "Yalamanchili H.K."xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/author | "Al-Ouran R."xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/pages | "301-316.e10"xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/title | "Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease."xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/31597093 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31597093 |
| http://purl.uniprot.org/citations/31597093 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31597093 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHJ0-mappedCitation-31597093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31597093 |