| http://purl.uniprot.org/citations/31597658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31597658 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs target complementary mRNAs for degradation or translational repression, reducing or preventing protein synthesis. In Caenorhabditis elegans, the transcription factor HBL-1 (Hunchback-like 1) promotes early larval (L2)-stage cell fates, and the let-7 family microRNAs temporally downregulate HBL-1 to enable the L2-to-L3 cell-fate progression. In parallel to let-7-family microRNAs, the conserved RNA-binding protein LIN-28 and its downstream gene lin-46 also act upstream of HBL-1 in regulating the L2-to-L3 cell-fate progression. The molecular function of LIN-46, and how the lin-28-lin-46 pathway regulates HBL-1, are not understood. Here, we report that the regulation of HBL-1 by the lin-28-lin-46 pathway is independent of the let-7/lin-4 microRNA complementary sites (LCSs) in the hbl-1 3'UTR, and involves stage-specific post-translational regulation of HBL-1 nuclear accumulation. We find that LIN-46 is necessary and sufficient to prevent nuclear accumulation of HBL-1. Our results illuminate that robust progression from L2 to L3 cell fates depends on the combination of two distinct modes of HBL-1 downregulation: decreased synthesis of HBL-1 via let-7-family microRNA activity, and decreased nuclear accumulation of HBL-1 via action of the lin-28-lin-46 pathway."xsd:string |
| http://purl.uniprot.org/citations/31597658 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.183111"xsd:string |
| http://purl.uniprot.org/citations/31597658 | http://purl.uniprot.org/core/author | "Ambros V."xsd:string |
| http://purl.uniprot.org/citations/31597658 | http://purl.uniprot.org/core/author | "Ilbay O."xsd:string |
| http://purl.uniprot.org/citations/31597658 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31597658 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/31597658 | http://purl.uniprot.org/core/pages | "dev183111"xsd:string |
| http://purl.uniprot.org/citations/31597658 | http://purl.uniprot.org/core/title | "Regulation of nuclear-cytoplasmic partitioning by the lin-28-lin-46 pathway reinforces microRNA repression of HBL-1 to confer robust cell-fate progression in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/31597658 | http://purl.uniprot.org/core/volume | "146"xsd:string |
| http://purl.uniprot.org/citations/31597658 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31597658 |
| http://purl.uniprot.org/citations/31597658 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31597658 |
| http://purl.uniprot.org/uniprot/#_G5EF06-mappedCitation-31597658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31597658 |
| http://purl.uniprot.org/uniprot/#_Q27GU0-mappedCitation-31597658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31597658 |
| http://purl.uniprot.org/uniprot/#_P92186-mappedCitation-31597658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31597658 |
| http://purl.uniprot.org/uniprot/#_Q9XYD3-mappedCitation-31597658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31597658 |
| http://purl.uniprot.org/uniprot/Q9XYD3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31597658 |
| http://purl.uniprot.org/uniprot/G5EF06 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31597658 |
| http://purl.uniprot.org/uniprot/P92186 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31597658 |
| http://purl.uniprot.org/uniprot/Q27GU0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31597658 |