| http://purl.uniprot.org/citations/31601623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31601623 | http://www.w3.org/2000/01/rdf-schema#comment | "In Arabidopsis, the IRE1A and IRE1B double mutant (ire1a/b) is unable to activate cytoplasmic splicing of bZIP60 mRNA and regulated IRE1-dependent decay under ER stress, whereas the mutant does not exhibit severe developmental defects under normal conditions. In this study, we focused on the Arabidopsis IRE1C gene, whose product lacks a sensor domain. We found that the ire1a/b/c triple mutant is lethal, and heterozygous IRE1C (ire1c/+) mutation in the ire1a/b mutants resulted in growth defects and reduction of the number of pollen grains. Genetic analysis revealed that IRE1C is required for male gametophyte development in the ire1a/b mutant background. Expression of a mutant form of IRE1B that lacks the luminal sensor domain (ΔLD) complemented a developmental defect in the male gametophyte in ire1a/b/c haplotype. In vivo, the ΔLD protein was activated by glycerol treatment that increases the composition of saturated lipid and was able to activate regulated IRE1-dependent decay but not bZIP60 splicing. These observations suggest that IRE1 contributes to plant development, especially male gametogenesis, using an alternative activation mechanism that bypasses the unfolded protein-sensing luminal domain."xsd:string |
| http://purl.uniprot.org/citations/31601623 | http://purl.org/dc/terms/identifier | "doi:10.26508/lsa.201900459"xsd:string |
| http://purl.uniprot.org/citations/31601623 | http://purl.uniprot.org/core/author | "Mochizuki T."xsd:string |
| http://purl.uniprot.org/citations/31601623 | http://purl.uniprot.org/core/author | "Iwata Y."xsd:string |
| http://purl.uniprot.org/citations/31601623 | http://purl.uniprot.org/core/author | "Koizumi N."xsd:string |
| http://purl.uniprot.org/citations/31601623 | http://purl.uniprot.org/core/author | "Nishioka N."xsd:string |
| http://purl.uniprot.org/citations/31601623 | http://purl.uniprot.org/core/author | "Hirata R."xsd:string |
| http://purl.uniprot.org/citations/31601623 | http://purl.uniprot.org/core/author | "Matsumura A."xsd:string |
| http://purl.uniprot.org/citations/31601623 | http://purl.uniprot.org/core/author | "Mishiba K.I."xsd:string |
| http://purl.uniprot.org/citations/31601623 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31601623 | http://purl.uniprot.org/core/name | "Life Sci Alliance"xsd:string |
| http://purl.uniprot.org/citations/31601623 | http://purl.uniprot.org/core/pages | "e201900459"xsd:string |
| http://purl.uniprot.org/citations/31601623 | http://purl.uniprot.org/core/title | "Unfolded protein-independent IRE1 activation contributes to multifaceted developmental processes in Arabidopsis."xsd:string |
| http://purl.uniprot.org/citations/31601623 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/31601623 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31601623 |
| http://purl.uniprot.org/citations/31601623 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31601623 |
| http://purl.uniprot.org/uniprot/#_F4KH40-mappedCitation-31601623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31601623 |
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| http://purl.uniprot.org/uniprot/#_Q8RX75-mappedCitation-31601623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31601623 |
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| http://purl.uniprot.org/uniprot/#_Q93VJ2-mappedCitation-31601623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31601623 |