| http://purl.uniprot.org/citations/31602465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31602465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31602465 | http://www.w3.org/2000/01/rdf-schema#comment | "The CFP1 CXXC zinc finger protein targets the SET1/COMPASS complex to non-methylated CpG rich promoters to implement tri-methylation of histone H3 Lys4 (H3K4me3). Although H3K4me3 is widely associated with gene expression, the effects of CFP1 loss vary, suggesting additional chromatin factors contribute to context dependent effects. Using a proteomics approach, we identified CFP1 associated proteins and an unexpected direct link between Caenorhabditis elegans CFP-1 and an Rpd3/Sin3 small (SIN3S) histone deacetylase complex. Supporting a functional connection, we find that mutants of COMPASS and SIN3 complex components genetically interact and have similar phenotypic defects including misregulation of common genes. CFP-1 directly binds SIN-3 through a region including the conserved PAH1 domain and recruits SIN-3 and the HDA-1/HDAC subunit to H3K4me3 enriched promoters. Our results reveal a novel role for CFP-1 in mediating interaction between SET1/COMPASS and a Sin3S HDAC complex at promoters."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkz880"xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkz880"xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Dong Y."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Dong Y."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Huang N."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Huang N."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Chen R.A."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Chen R.A."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Caron M."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Caron M."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Coute Y."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Coute Y."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Ahringer J."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Ahringer J."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Appert A."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Appert A."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Bedet C."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Bedet C."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Beurton F."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Beurton F."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Cluet D."xsd:string |
| http://purl.uniprot.org/citations/31602465 | http://purl.uniprot.org/core/author | "Cluet D."xsd:string |