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http://purl.uniprot.org/citations/31603112http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31603112http://www.w3.org/2000/01/rdf-schema#comment"

Context

Through the expression of different immunomodulatory molecules, mesenchymal stem cells (MSCs) play a significant role in the regulation of immune responses against tumor cells. Herein, the expression of major histocompatibility complex class I polypeptide-related sequence B (MIC B) as an immunomodulatory molecule was investigated on adipose-derived stem cells (ASCs) isolated from breast cancer patients (Stage II and III) and healthy individuals.

Materials and methods

ASCs were isolated enzymatically, and the expression of MIC B was measured using quantitative real-time polymerase chain reaction method before and after treatment with interferon γ (IFN-γ). The concentration of MIC B in the supernatant of ASCs and also sera of breast cancer and normal individuals were determined using ELISA method.

Results

The expression of MIC B in normal ASCs and Stage II ASCs was higher than Stage III ASCs. However, after treatment with IFN-γ expression of MIC B in ASCs was conversely changed as cancer ASCs showed approximately 3.5 fold higher expression of MIC B compared to normal ASCs. The mRNA expression of MIC B in Stage III, Stage II, and normal ASCs showed 61 (P = 0.02), 13 (P = 0.01) and 3 (P > 0.05) fold higher expression after stimulation with IFN-γ compared to cells with no stimulation.

Conclusion

Expression of MIC B and upregulation of this molecule in response to IFN-γ in cancer ASCs draw attention to the effective role of MSCs in the tumor microenvironment. However, more studies will be needed to further elucidate Natural-killer Group 2, member D (NKG2D) ligands-dependent immunomodulatory roles of ASCs in the tumor progression."xsd:string
http://purl.uniprot.org/citations/31603112http://purl.org/dc/terms/identifier"doi:10.4103/jcrt.jcrt_866_16"xsd:string
http://purl.uniprot.org/citations/31603112http://purl.uniprot.org/core/author"Ghaderi A."xsd:string
http://purl.uniprot.org/citations/31603112http://purl.uniprot.org/core/author"Talei A.R."xsd:string
http://purl.uniprot.org/citations/31603112http://purl.uniprot.org/core/author"Razmkhah M."xsd:string
http://purl.uniprot.org/citations/31603112http://purl.uniprot.org/core/author"Mansourabadi Z."xsd:string
http://purl.uniprot.org/citations/31603112http://purl.uniprot.org/core/author"Mohtasebi M.S."xsd:string
http://purl.uniprot.org/citations/31603112http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/31603112http://purl.uniprot.org/core/name"J Cancer Res Ther"xsd:string
http://purl.uniprot.org/citations/31603112http://purl.uniprot.org/core/pages"1067-1072"xsd:string
http://purl.uniprot.org/citations/31603112http://purl.uniprot.org/core/title"Expression of major histocompatibility complex class I polypeptide-related sequence B in adipose-derived stem cells from breast cancer patients and normal individuals."xsd:string
http://purl.uniprot.org/citations/31603112http://purl.uniprot.org/core/volume"15"xsd:string
http://purl.uniprot.org/citations/31603112http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31603112
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