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http://purl.uniprot.org/citations/31625350http://www.w3.org/2000/01/rdf-schema#comment"

Background

Both the extracellular matrix molecule tenascin-C (Tn-C) and tissue inhibitors of metalloproteinases (TIMPs) have a role in tissue injury, inflammation, and remodeling. In this pilot study, we tried to evaluate the role of these markers in acute kidney injury (AKI).

Methods

A total of 52 subjects were enrolled in this study. Group 1 consisted of 27 patients with AKI (stage 1, 2, and 3), and Group 2 consisted of 25 age- and gender-matched healthy subjects. Serum and urine samples (to determine Tn-C and TIMP-1) were obtained from the participants at the beginning of the study. Second samples were obtained from Group 1 patients when renal function improved (at discharge).

Results

Serum TIMP-1 concentrations (admission and discharge) were higher in Group 1 than Group 2 (p = 0.0001 for both comparisons). Tn-C excretion in spot urine was significantly higher in healthy controls than at the admission levels of the patient group (p = 0.036). However, TIMP-1 excretion in spot urine was lower in healthy controls than in admission and discharge levels of the patient group (p = 0.0001 for both comparisons).

Conclusions

Our results show that these biomarkers (especially TIMP-1) may have a role in the pathophysiology of AKI. Further studies are needed in this field."xsd:string
http://purl.uniprot.org/citations/31625350http://purl.org/dc/terms/identifier"doi:10.7754/clin.lab.2019.190233"xsd:string
http://purl.uniprot.org/citations/31625350http://purl.uniprot.org/core/author"Demir E."xsd:string
http://purl.uniprot.org/citations/31625350http://purl.uniprot.org/core/author"Gedikbasi A."xsd:string
http://purl.uniprot.org/citations/31625350http://purl.uniprot.org/core/author"Ozkan H."xsd:string
http://purl.uniprot.org/citations/31625350http://purl.uniprot.org/core/author"Demir B."xsd:string
http://purl.uniprot.org/citations/31625350http://purl.uniprot.org/core/author"Dogan H."xsd:string
http://purl.uniprot.org/citations/31625350http://purl.uniprot.org/core/author"Okuturlar Y."xsd:string
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http://purl.uniprot.org/citations/31625350http://purl.uniprot.org/core/author"Harmankaya O."xsd:string
http://purl.uniprot.org/citations/31625350http://purl.uniprot.org/core/author"Hursitoglu M."xsd:string
http://purl.uniprot.org/citations/31625350http://purl.uniprot.org/core/author"Okuturlar O."xsd:string
http://purl.uniprot.org/citations/31625350http://purl.uniprot.org/core/author"Serin S.O."xsd:string
http://purl.uniprot.org/citations/31625350http://purl.uniprot.org/core/author"Utku I.K."xsd:string
http://purl.uniprot.org/citations/31625350http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/31625350http://purl.uniprot.org/core/name"Clin Lab"xsd:string
http://purl.uniprot.org/citations/31625350http://purl.uniprot.org/core/title"Serum Levels and Urinary Excretion of Tenascin-C and TIMP-1 in Acute Kidney Injury."xsd:string
http://purl.uniprot.org/citations/31625350http://purl.uniprot.org/core/volume"65"xsd:string
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