| http://purl.uniprot.org/citations/31628042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31628042 | http://www.w3.org/2000/01/rdf-schema#comment | "GTP cyclohydrolase I (GTPCH), 6-pyruvoyltetrahydropterin synthase (PTPS), and sepiapterin reductase (SR) are sequentially responsible for de novo synthesis of tetrahydrobiopterin (BH4), a known co-factor for nitric oxide synthase (NOS). The implication of BH4-biosynthesis process in tumorigenesis remains to be investigated. Here, we show that PTPS, which is highly expressed in early-stage colorectal cancer, is phosphorylated at Thr 58 by AMPK under hypoxia; this phosphorylation promotes PTPS binding to LTBP1 and subsequently drives iNOS-mediated LTBP1 S-nitrosylation through proximal-coupling BH4 production within the PTPS/iNOS/LTBP1 complex. In turn, LTBP1 S-nitrosylation results in proteasome-dependent LTBP1 protein degradation, revealing an inverse relationship between PTPS pT58 and LTBP1 stability. Physiologically, the repressive effect of PTPS on LTBP1 leads to impaired transforming growth factor β (TGF-β) secretion and thereby maintains tumor cell growth under hypoxia. Our findings illustrate a molecular mechanism underlying the regulation of LTBP1-TGF-β signaling by the BH4-biosynthesis pathway and highlight the specific requirement of PTPS for tumor growth."xsd:string |
| http://purl.uniprot.org/citations/31628042 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2019.09.018"xsd:string |
| http://purl.uniprot.org/citations/31628042 | http://purl.uniprot.org/core/author | "Chen T."xsd:string |
| http://purl.uniprot.org/citations/31628042 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/31628042 | http://purl.uniprot.org/core/author | "Huang W."xsd:string |
| http://purl.uniprot.org/citations/31628042 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/31628042 | http://purl.uniprot.org/core/author | "Ma C."xsd:string |
| http://purl.uniprot.org/citations/31628042 | http://purl.uniprot.org/core/author | "Zhao Q."xsd:string |
| http://purl.uniprot.org/citations/31628042 | http://purl.uniprot.org/core/author | "Zheng K."xsd:string |
| http://purl.uniprot.org/citations/31628042 | http://purl.uniprot.org/core/author | "Zhuo L."xsd:string |
| http://purl.uniprot.org/citations/31628042 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31628042 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/31628042 | http://purl.uniprot.org/core/pages | "95-107.e5"xsd:string |
| http://purl.uniprot.org/citations/31628042 | http://purl.uniprot.org/core/title | "PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia."xsd:string |
| http://purl.uniprot.org/citations/31628042 | http://purl.uniprot.org/core/volume | "77"xsd:string |
| http://purl.uniprot.org/citations/31628042 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31628042 |
| http://purl.uniprot.org/citations/31628042 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31628042 |
| http://purl.uniprot.org/uniprot/#_B4DST8-mappedCitation-31628042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31628042 |
| http://purl.uniprot.org/uniprot/#_B4DRF7-mappedCitation-31628042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31628042 |
| http://purl.uniprot.org/uniprot/#_B4DZD1-mappedCitation-31628042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31628042 |
| http://purl.uniprot.org/uniprot/#_B4DNR7-mappedCitation-31628042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31628042 |
| http://purl.uniprot.org/uniprot/#_B7ZLY3-mappedCitation-31628042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31628042 |
| http://purl.uniprot.org/uniprot/#_Q14766-mappedCitation-31628042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31628042 |
| http://purl.uniprot.org/uniprot/Q14766 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31628042 |