| http://purl.uniprot.org/citations/31630209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31630209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31630209 | http://www.w3.org/2000/01/rdf-schema#comment | "Influenza A virus (IAV) triggers the infected lung to produce IL-1 and recruit neutrophils. Unlike IL-1β, however, little is known about IL-1α in terms of its mechanism of induction, action and physiological relevance to the host immunity against IAV infection. In particular, whether Z-DNA-binding protein 1 (ZBP1), a key molecule for IAV-induced cell death, is involved in the IL-1α induction, neutrophil infiltration and the physiological outcome has not been elucidated. Here, we show in a murine model that the IAV-induced IL-1α is mediated solely by ZBP1, in an NLRP3-inflammasome-independent manner, and is required for the optimal IL-1β production followed by the formation of neutrophil extracellular traps (NETs). During IAV infection, ZBP1 displays a dual role in anti-IAV immune responses mediated by neutrophils, resulting in either protective or pathological outcomes in vivo. Thus, ZBP1-mediated IL-1α production is the key initial step of IAV-infected NETs, regulating the duality of the consequent lung inflammation."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxz070"xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxz070"xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Imai Y."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Imai Y."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Kusakabe T."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Kusakabe T."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Kubo A."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Kubo A."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Ishii K.J."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Ishii K.J."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Kobiyama K."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Kobiyama K."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Coban C."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Coban C."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Kuroda E."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Kuroda E."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Lelliott P."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Lelliott P."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Momota M."xsd:string |
| http://purl.uniprot.org/citations/31630209 | http://purl.uniprot.org/core/author | "Momota M."xsd:string |