| http://purl.uniprot.org/citations/31633020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31633020 | http://www.w3.org/2000/01/rdf-schema#comment | "Posthemorrhagic hydrocephalus (PHH) in premature infants is a common neurological disorder treated with invasive neurosurgical interventions. Patients with PHH lack effective therapeutic interventions and suffer chronic comorbidities. Here, we report a murine lysophosphatidic acid (LPA)-induced postnatal PHH model that maps neurodevelopmentally to premature infants, a clinically accessible high-risk population, and demonstrates ventriculomegaly with increased intracranial pressure. Administration of LPA, a blood-borne signaling lipid, acutely disrupted the ependymal cells that generate CSF flow, which was followed by cell death, phagocytosis, and ventricular surface denudation. This mechanism is distinct from a previously reported fetal model that induces PHH through developmental alterations. Analyses of LPA receptor-null mice identified LPA1 and LPA3 as key mediators of PHH. Pharmacological blockade of LPA1 prevented PHH in LPA-injected animals, supporting the medical tractability of LPA receptor antagonists in preventing PHH and negative CNS sequelae in premature infants."xsd:string |
| http://purl.uniprot.org/citations/31633020 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.aax2011"xsd:string |
| http://purl.uniprot.org/citations/31633020 | http://purl.uniprot.org/core/author | "Chun J."xsd:string |
| http://purl.uniprot.org/citations/31633020 | http://purl.uniprot.org/core/author | "Kihara Y."xsd:string |
| http://purl.uniprot.org/citations/31633020 | http://purl.uniprot.org/core/author | "Kennedy G."xsd:string |
| http://purl.uniprot.org/citations/31633020 | http://purl.uniprot.org/core/author | "Blaho V.A."xsd:string |
| http://purl.uniprot.org/citations/31633020 | http://purl.uniprot.org/core/author | "Frantz A.J."xsd:string |
| http://purl.uniprot.org/citations/31633020 | http://purl.uniprot.org/core/author | "Lummis N.C."xsd:string |
| http://purl.uniprot.org/citations/31633020 | http://purl.uniprot.org/core/author | "Sanchez-Pavon P."xsd:string |
| http://purl.uniprot.org/citations/31633020 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31633020 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/31633020 | http://purl.uniprot.org/core/pages | "eaax2011"xsd:string |
| http://purl.uniprot.org/citations/31633020 | http://purl.uniprot.org/core/title | "LPA1/3 overactivation induces neonatal posthemorrhagic hydrocephalus through ependymal loss and ciliary dysfunction."xsd:string |
| http://purl.uniprot.org/citations/31633020 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/31633020 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31633020 |
| http://purl.uniprot.org/citations/31633020 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31633020 |
| http://purl.uniprot.org/uniprot/#_P61793-mappedCitation-31633020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31633020 |
| http://purl.uniprot.org/uniprot/#_A0A571BEW5-mappedCitation-31633020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31633020 |
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| http://purl.uniprot.org/uniprot/#_A2AMJ0-mappedCitation-31633020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31633020 |
| http://purl.uniprot.org/uniprot/#_A2AMJ1-mappedCitation-31633020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31633020 |
| http://purl.uniprot.org/uniprot/#_F6S365-mappedCitation-31633020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31633020 |
| http://purl.uniprot.org/uniprot/#_Q149R9-mappedCitation-31633020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31633020 |
| http://purl.uniprot.org/uniprot/#_G3X9K0-mappedCitation-31633020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31633020 |