| http://purl.uniprot.org/citations/31641109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31641109 | http://www.w3.org/2000/01/rdf-schema#comment | "The DNA mismatch repair (MMR) pathway is responsible for the repair of base-base mismatches and insertion/deletion loops that arise during DNA replication. MMR deficiency is currently estimated to be present in 15-17% of colorectal cancer cases and 30% of endometrial cancers. MLH1 is one of the key proteins involved in the MMR pathway. Inhibition of a number of mitochondrial genes, including POLG and PINK1 can induce synthetic lethality in MLH1-deficient cells. Here we demonstrate for the first time that loss of MLH1 is associated with a deregulated mitochondrial metabolism, with reduced basal oxygen consumption rate and reduced spare respiratory capacity. Furthermore, MLH1-deficient cells display a significant reduction in activity of the respiratory chain Complex I. As a functional consequence of this perturbed mitochondrial metabolism, MLH1-deficient cells have a reduced anti-oxidant response and show increased sensitivity to reactive oxidative species (ROS)-inducing drugs. Taken together, our results provide evidence for an intrinsic mitochondrial dysfunction in MLH1-deficient cells and a requirement for MLH1 in the regulation of mitochondrial function."xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-019-2018-y"xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/author | "Gay L."xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/author | "Yao Z."xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/author | "Williams M."xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/author | "Martin S.A."xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/author | "Freitas M.O."xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/author | "McDonald S.A.C."xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/author | "Rashid S."xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/author | "Chelala C."xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/author | "Cucchi D."xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/author | "Szabadkai G."xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/author | "Silver A."xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/author | "Suraweera N."xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/author | "Bridge G."xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/pages | "795"xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/title | "MLH1 deficiency leads to deregulated mitochondrial metabolism."xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/31641109 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31641109 |
| http://purl.uniprot.org/citations/31641109 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31641109 |
| http://purl.uniprot.org/uniprot/#_A5JTV1-mappedCitation-31641109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31641109 |