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Objective

To study the expression of ubiquitin C-terminal hydrolase-L3 (UCH-L3) in epithelial ovarian cancer (EOC) tissues, and to analyze the relationship between UCH-L3 expression and the clinic pathological characteristics and prognosis of EOC patients.

Methods

Immunohistochemical analysis was performed to evaluate UCH-L3 expression in different ovarian epithelial tissue specimens. The correlation between UCH-L3 expression and clinical pathologic parameters, prognosis and of EOC was statistically analyzed.

Results

The expression level of UCH-L3 in EOC was higher than that in benign ovarian tumor and normal ovary (P < 0.05). The positive expression level of UCH-L3 in late FIGO group, high-level group, group with intraperitoneal metastasis were significantly higher than that in early FIGO group (P=0.006), low-level group (P=0.001), group without intraperitoneal metastasis (P=0.032). There was no significant difference in survival time between the high and low expression groups of UCH-L3.

Conclusion

UCH-L3 may play a role in EOC pathogenesis and progression."xsd:string
http://purl.uniprot.org/citations/31642235http://purl.uniprot.org/core/author"Wang H.J."xsd:string
http://purl.uniprot.org/citations/31642235http://purl.uniprot.org/core/author"Li T.T."xsd:string
http://purl.uniprot.org/citations/31642235http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/31642235http://purl.uniprot.org/core/name"Sichuan Da Xue Xue Bao Yi Xue Ban"xsd:string
http://purl.uniprot.org/citations/31642235http://purl.uniprot.org/core/pages"556-560"xsd:string
http://purl.uniprot.org/citations/31642235http://purl.uniprot.org/core/title"[UCH-L3 Expression in Epithelial Ovarian Cancer and Its Clinical Significance]."xsd:string
http://purl.uniprot.org/citations/31642235http://purl.uniprot.org/core/volume"50"xsd:string
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