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http://purl.uniprot.org/citations/31645358http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31645358http://www.w3.org/2000/01/rdf-schema#comment"During the extended prophase of Drosophila gametogenesis, spermatocytes undergo robust gene transcription and store many transcripts in the cytoplasm in a repressed state, until translational activation of select mRNAs in later steps of spermatogenesis. Here, we characterize the Drosophila Doublefault (Dbf) protein as a C2H2 zinc-finger protein, primarily expressed in testes, that is required for normal meiotic division and spermiogenesis. Loss of Dbf causes premature centriole disengagement and affects spindle structure, chromosome segregation and cytokinesis. We show that Dbf interacts with the RNA-binding protein Syncrip/hnRNPQ, a key regulator of localized translation in Drosophila We propose that the pleiotropic effects of dbf loss-of-function mutants are associated with the requirement of dbf function for translation of specific transcripts in spermatocytes. In agreement with this hypothesis, Dbf protein binds cyclin B mRNA and is essential for translation of cyclin B in mature spermatocytes."xsd:string
http://purl.uniprot.org/citations/31645358http://purl.org/dc/terms/identifier"doi:10.1242/dev.183053"xsd:string
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/author"Fuller M.T."xsd:string
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/author"Giansanti M.G."xsd:string
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/author"Sechi S."xsd:string
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/author"Callaini G."xsd:string
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/author"Riparbelli M.G."xsd:string
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/author"Schinina E."xsd:string
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/author"Di Francesco L."xsd:string
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/author"Gottardo M."xsd:string
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/author"Frappaolo A."xsd:string
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/author"Saggio I."xsd:string
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/author"Szafer-Glusman E."xsd:string
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/author"Burla R."xsd:string
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/author"Karimpour-Ghahnavieh A."xsd:string
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/name"Development"xsd:string
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/pages"dev183053"xsd:string
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/title"Drosophila Doublefault protein coordinates multiple events during male meiosis by controlling mRNA translation."xsd:string
http://purl.uniprot.org/citations/31645358http://purl.uniprot.org/core/volume"146"xsd:string
http://purl.uniprot.org/citations/31645358http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31645358
http://purl.uniprot.org/citations/31645358http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/31645358
http://purl.uniprot.org/uniprot/#_A0A0B4KHH8-mappedCitation-31645358http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31645358
http://purl.uniprot.org/uniprot/#_A0A0B4KHI4-mappedCitation-31645358http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31645358