| http://purl.uniprot.org/citations/31645367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31645367 | http://www.w3.org/2000/01/rdf-schema#comment | "Core 1-derived mucin-type O-glycans (O-glycans) are a major component of gastric mucus with an unclear role. To address this, we generated mice lacking gastric epithelial O-glycans (GEC C1galt1-/-). GEC C1galt1-/-mice exhibited spontaneous gastritis that progressed to adenocarcinoma with ∼80% penetrance by 1 yr. GEC C1galt1-/-gastric epithelium exhibited defective expression of a major mucus forming O-glycoprotein Muc5AC relative to WT controls, which was associated with impaired gastric acid homeostasis. Inflammation and tumorigenesis in GEC C1galt1-/-stomach were concurrent with activation of caspases 1 and 11 (Casp1/11)-dependent inflammasome. GEC C1galt1-/-mice genetically lacking Casp1/11 had reduced gastritis and gastric cancer progression. Notably, expression of Tn antigen, a truncated form of O-glycan, and CASP1 activation was associated with tumor progression in gastric cancer patients. These results reveal a critical role of O-glycosylation in gastric homeostasis and the protection of the gastric mucosa from Casp1-mediated gastric inflammation and cancer."xsd:string |
| http://purl.uniprot.org/citations/31645367 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20182325"xsd:string |
| http://purl.uniprot.org/citations/31645367 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/31645367 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/31645367 | http://purl.uniprot.org/core/author | "Bai X."xsd:string |
| http://purl.uniprot.org/citations/31645367 | http://purl.uniprot.org/core/author | "Xia L."xsd:string |
| http://purl.uniprot.org/citations/31645367 | http://purl.uniprot.org/core/author | "Fu J."xsd:string |
| http://purl.uniprot.org/citations/31645367 | http://purl.uniprot.org/core/author | "Bergstrom K."xsd:string |
| http://purl.uniprot.org/citations/31645367 | http://purl.uniprot.org/core/author | "Shan X."xsd:string |
| http://purl.uniprot.org/citations/31645367 | http://purl.uniprot.org/core/author | "McGee S."xsd:string |
| http://purl.uniprot.org/citations/31645367 | http://purl.uniprot.org/core/author | "McDaniel J.M."xsd:string |
| http://purl.uniprot.org/citations/31645367 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31645367 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/31645367 | http://purl.uniprot.org/core/pages | "e20182325"xsd:string |
| http://purl.uniprot.org/citations/31645367 | http://purl.uniprot.org/core/title | "Core 1-derived mucin-type O-glycosylation protects against spontaneous gastritis and gastric cancer."xsd:string |
| http://purl.uniprot.org/citations/31645367 | http://purl.uniprot.org/core/volume | "217"xsd:string |
| http://purl.uniprot.org/citations/31645367 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31645367 |
| http://purl.uniprot.org/citations/31645367 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31645367 |
| http://purl.uniprot.org/uniprot/#_Q9JJ06-mappedCitation-31645367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31645367 |
| http://purl.uniprot.org/uniprot/Q9JJ06 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31645367 |