DESCRIBE <http://purl.uniprot.org/citations/31659102>

Subject	Predicate	Object
http://purl.uniprot.org/citations/31659102	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31659102	http://www.w3.org/2000/01/rdf-schema#comment	" Background/aim The biological importance of the caudal-related homeobox transcription factor CDX2 in acquiring resistance to anticancer drugs has been studied in ovarian mucinous carcinoma. CDX2 promotes the expression of multidrug resistance 1 (MDR1) and confers resistance to paclitaxel. The regenerating islet-derived family member 4 (REG4) gene is a potential target gene of CDX2. In this study, we investigated the relationship between the expression of CDX2 and Reg IV and the regulation of Reg IV expression and examined novel chemotherapeutic regimens. Materials and methods The regulation of Reg IV expression by CDX2 and sensitivity of 5-fluorouracil (5-FU) were evaluated using ovarian mucinous cancer cell lines. Results The correlation of CDX2 with Reg IV expression was demonstrated in ovarian mucinous carcinoma. Reg IV expression was enhanced by transfection of CDX2 and was suppressed by inhibition of CDX2 expression. OMC-3 cells with ectopically overexpressed CDX2 showed enhanced apoptosis and sensitivity to 5-FU. Conclusion CDX2 promotes resistance to paclitaxel and sensitivity to 5-FU. Novel 5-FU-based chemotherapy based on CDX2 may be used in ovarian mucinous carcinoma."xsd:string
http://purl.uniprot.org/citations/31659102	http://purl.org/dc/terms/identifier	"doi:10.21873/cgp.20151"xsd:string
http://purl.uniprot.org/citations/31659102	http://purl.uniprot.org/core/author	"Kudo Y."xsd:string
http://purl.uniprot.org/citations/31659102	http://purl.uniprot.org/core/author	"Sekine M."xsd:string
http://purl.uniprot.org/citations/31659102	http://purl.uniprot.org/core/author	"Sugimoto J."xsd:string
http://purl.uniprot.org/citations/31659102	http://purl.uniprot.org/core/author	"Hirata E."xsd:string
http://purl.uniprot.org/citations/31659102	http://purl.uniprot.org/core/author	"Koh I."xsd:string
http://purl.uniprot.org/citations/31659102	http://purl.uniprot.org/core/author	"Nosaka S."xsd:string
http://purl.uniprot.org/citations/31659102	http://purl.uniprot.org/core/date	"2019"xsd:gYear
http://purl.uniprot.org/citations/31659102	http://purl.uniprot.org/core/name	"Cancer Genomics Proteomics"xsd:string
http://purl.uniprot.org/citations/31659102	http://purl.uniprot.org/core/pages	"481-490"xsd:string
http://purl.uniprot.org/citations/31659102	http://purl.uniprot.org/core/title	"Regulation of REG4 Expression and Prediction of 5-Fluorouracil Sensitivity by CDX2 in Ovarian Mucinous Carcinoma."xsd:string
http://purl.uniprot.org/citations/31659102	http://purl.uniprot.org/core/volume	"16"xsd:string
http://purl.uniprot.org/citations/31659102	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/31659102
http://purl.uniprot.org/citations/31659102	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/31659102
http://purl.uniprot.org/uniprot/#_A0A076MKN9-mappedCitation-31659102	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/31659102
http://purl.uniprot.org/uniprot/#_A0A0M3L9V7-mappedCitation-31659102	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/31659102
http://purl.uniprot.org/uniprot/#_Q9BYZ8-mappedCitation-31659102	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/31659102
http://purl.uniprot.org/uniprot/#_Q99626-mappedCitation-31659102	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/31659102
http://purl.uniprot.org/uniprot/Q9BYZ8	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/31659102
http://purl.uniprot.org/uniprot/Q99626	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/31659102
http://purl.uniprot.org/uniprot/A0A0M3L9V7	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/31659102
http://purl.uniprot.org/uniprot/A0A076MKN9	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/31659102