| http://purl.uniprot.org/citations/31663027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31663027 | http://www.w3.org/2000/01/rdf-schema#comment | "PIP3-dependent Rac exchanger 1 (P-Rex1) is activated downstream of G protein-coupled receptors to promote neutrophil migration and metastasis. The structure of more than half of the enzyme and its regulatory G protein binding site are unknown. Our 3.2 Å cryo-EM structure of the P-Rex1-Gβγ complex reveals that the carboxyl-terminal half of P-Rex1 adopts a complex fold most similar to those of Legionella phosphoinositide phosphatases. Although catalytically inert, the domain coalesces with a DEP domain and two PDZ domains to form an extensive docking site for Gβγ. Hydrogen-deuterium exchange mass spectrometry suggests that Gβγ binding induces allosteric changes in P-Rex1, but functional assays indicate that membrane localization is also required for full activation. Thus, a multidomain assembly is key to the regulation of P-Rex1 by Gβγ and the formation of a membrane-localized scaffold optimized for recruitment of other signaling proteins such as PKA and PTEN."xsd:string |
| http://purl.uniprot.org/citations/31663027 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.aax8855"xsd:string |
| http://purl.uniprot.org/citations/31663027 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/31663027 | http://purl.uniprot.org/core/author | "Gutkind J.S."xsd:string |
| http://purl.uniprot.org/citations/31663027 | http://purl.uniprot.org/core/author | "Tesmer J.J.G."xsd:string |
| http://purl.uniprot.org/citations/31663027 | http://purl.uniprot.org/core/author | "Urata S."xsd:string |
| http://purl.uniprot.org/citations/31663027 | http://purl.uniprot.org/core/author | "Ravala S.K."xsd:string |
| http://purl.uniprot.org/citations/31663027 | http://purl.uniprot.org/core/author | "Cianfrocco M.A."xsd:string |
| http://purl.uniprot.org/citations/31663027 | http://purl.uniprot.org/core/author | "Cash J.N."xsd:string |
| http://purl.uniprot.org/citations/31663027 | http://purl.uniprot.org/core/author | "Avramova L.V."xsd:string |
| http://purl.uniprot.org/citations/31663027 | http://purl.uniprot.org/core/author | "Shost M.D."xsd:string |
| http://purl.uniprot.org/citations/31663027 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31663027 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/31663027 | http://purl.uniprot.org/core/pages | "eaax8855"xsd:string |
| http://purl.uniprot.org/citations/31663027 | http://purl.uniprot.org/core/title | "Cryo-electron microscopy structure and analysis of the P-Rex1-Gbetagamma signaling scaffold."xsd:string |
| http://purl.uniprot.org/citations/31663027 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/31663027 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31663027 |
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| http://purl.uniprot.org/uniprot/P62871 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31663027 |
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