| http://purl.uniprot.org/citations/31664133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31664133 | http://www.w3.org/2000/01/rdf-schema#comment | "HSP47 is required for the production of collagen and serves an important role in tissue remodeling, a pathophysiologic mechanism of chronic rhinosinusitis (CRS). We investigated the relationship between HSP47 expression and tissue remodeling in CRS. We also determined the underlying molecular mechanisms of TGF-β1-induced HSP47 and extracellular matrix (ECM) production in nasal fibroblasts. HSP47, α-SMA, fibronectin, and collagen type I expression levels were measured using real-time PCR, western blotting, and immunofluorescence staining. Fibroblast migration was analyzed using scratch and transwell migration assays. Contractile activity was measured with a collagen gel contraction assay. HSP47 is increased in patients with CRS without nasal polyps. TGF-β1 induced HSP47 expression in nasal fibroblasts. Myofibroblast differentiation and ECM production, which are induced by TGF-β1, were inhibited by siHSP47. We also confirmed that the Smad2/3 signaling pathway is involved in TGF-β1-induced HSP47 expression in nasal fibroblasts. In a functional assay, TGF-β1-enhanced migration and contraction ability were inhibited by HSP47 knockout. Glucocorticoid reversed the stimulatory effects of TGF-β1 on HSP47 expression and ECM production in nasal fibroblasts and ex vivo organ cultures. HSP47 expression is involved in TGF-β1-induced myofibroblast differentiation and ECM production through the Smad2/3 signaling pathway, which might contribute to tissue remodeling in chronic rhinosinusitis."xsd:string |
| http://purl.uniprot.org/citations/31664133 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-019-52064-1"xsd:string |
| http://purl.uniprot.org/citations/31664133 | http://purl.uniprot.org/core/author | "Kim H.J."xsd:string |
| http://purl.uniprot.org/citations/31664133 | http://purl.uniprot.org/core/author | "Lee H.M."xsd:string |
| http://purl.uniprot.org/citations/31664133 | http://purl.uniprot.org/core/author | "Park J.H."xsd:string |
| http://purl.uniprot.org/citations/31664133 | http://purl.uniprot.org/core/author | "Yang H.W."xsd:string |
| http://purl.uniprot.org/citations/31664133 | http://purl.uniprot.org/core/author | "Park I.H."xsd:string |
| http://purl.uniprot.org/citations/31664133 | http://purl.uniprot.org/core/author | "Shin J.M."xsd:string |
| http://purl.uniprot.org/citations/31664133 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31664133 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/31664133 | http://purl.uniprot.org/core/pages | "15563"xsd:string |
| http://purl.uniprot.org/citations/31664133 | http://purl.uniprot.org/core/title | "TGF-beta1-induced HSP47 regulates extracellular matrix accumulation via Smad2/3 signaling pathways in nasal fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/31664133 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/31664133 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31664133 |
| http://purl.uniprot.org/citations/31664133 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31664133 |
| http://purl.uniprot.org/uniprot/#_A0A078BBI5-mappedCitation-31664133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31664133 |
| http://purl.uniprot.org/uniprot/#_A0A078BC11-mappedCitation-31664133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31664133 |
| http://purl.uniprot.org/uniprot/#_A0A078BCJ0-mappedCitation-31664133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31664133 |
| http://purl.uniprot.org/uniprot/#_A8K259-mappedCitation-31664133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31664133 |
| http://purl.uniprot.org/uniprot/#_A0A078BCH8-mappedCitation-31664133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31664133 |
| http://purl.uniprot.org/uniprot/#_A0A078BFK3-mappedCitation-31664133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31664133 |
| http://purl.uniprot.org/uniprot/#_A0A510GAF6-mappedCitation-31664133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31664133 |
| http://purl.uniprot.org/uniprot/#_A0A499FJK2-mappedCitation-31664133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31664133 |
| http://purl.uniprot.org/uniprot/#_B2C8Z3-mappedCitation-31664133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31664133 |