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http://purl.uniprot.org/citations/3166457http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/3166457http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/3166457http://www.w3.org/2000/01/rdf-schema#comment"Four cDNA clones encoding a proteinase which facilitates skin invasion by schistosome parasites were isolated by screening a schistosome sporocyst cDNA library, using an oligonucleotide probe containing sequences complementary to predicted 5'-translated regions of its RNA. The amino acid sequence of the enzyme, as deduced from the DNA sequence of the clones, indicates that the enzyme is a serine protease which in many respects is similar to vertebrate pancreatic elastases, although regions outside of the putative active site, binding pocket, and amino-terminal cysteines differ significantly. Regulation of expression of the enzyme occurs at the level of mRNA transcription as well as posttranslationally, the latter involving the processing of a previously unidentified pre-proenzyme (zymogen) sequence. In situ hybridization of the cDNA clones to tissue sections of developing larvae indicates that the enzyme is synthesized within a discrete time frame in specialized cells of the organism."xsd:string
http://purl.uniprot.org/citations/3166457http://purl.org/dc/terms/identifier"doi:10.1016/s0021-9258(18)37688-9"xsd:string
http://purl.uniprot.org/citations/3166457http://purl.org/dc/terms/identifier"doi:10.1016/s0021-9258(18)37688-9"xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/author"Agabian N."xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/author"Agabian N."xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/author"McKerrow J.H."xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/author"McKerrow J.H."xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/author"Barr P.J."xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/author"Barr P.J."xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/author"Newport G.R."xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/author"Newport G.R."xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/author"Hedstrom R."xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/author"Hedstrom R."xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/author"McGarrigle L."xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/author"McGarrigle L."xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/author"Petitt M."xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/author"Petitt M."xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/date"1988"xsd:gYear
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/date"1988"xsd:gYear
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/pages"13179-13184"xsd:string
http://purl.uniprot.org/citations/3166457http://purl.uniprot.org/core/pages"13179-13184"xsd:string