| http://purl.uniprot.org/citations/31669265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31669265 | http://www.w3.org/2000/01/rdf-schema#comment | "During stress conditions such as pressure overload and acute ischemia, the myocardial endothelium releases neuregulin-1β (NRG-1), which acts as a cardioprotective factor and supports recovery of the heart. Recently, we demonstrated that recombinant human (rh)NRG-1 enhances glucose uptake in neonatal rat ventricular myocytes via the ErbB2/ErbB4 heterodimer and PI3Kα. The present study aimed to further elucidate the mechanism whereby rhNRG-1 activates glucose uptake in comparison to the well-established insulin and to extend the findings to adult models. Combinations of rhNRG-1 with increasing doses of insulin did not yield any additive effect on glucose uptake measured as 3H-deoxy-d-glucose incorporation, indicating that the mechanisms of the two stimuli are similar. In c-Myc-GLUT4-mCherry-transfected neonatal rat cardiomyocytes, rhNRG-1 increased sarcolemmal GLUT4 by 16-fold, similar to insulin. In contrast to insulin, rhNRG-1 did not phosphorylate IRS-1 at Tyr612, indicating that IRS-1 is not implicated in the signal transmission. Treatment of neonatal rats with rhNRG-1 induced a signaling response comparable with that observed in vitro, including increased ErbB4-pTyr1284, Akt-pThr308 and Erk1/2-pThr202/Tyr204. In contrast, in adult cardiomyocytes rhNRG-1 only increased the phosphorylation of Erk1/2 without having any significant effect on Akt and AS160 phosphorylation and glucose uptake, suggesting that rhNRG-1 function in neonatal cardiomyocytes differs from that in adult cardiomyocytes. In conclusion, our results show that similar to insulin, rhNRG-1 can induce glucose uptake by activating the PI3Kα-Akt-AS160 pathway and GLUT4 translocation. Unlike insulin, the rhNRG-1-induced effect is not mediated by IRS proteins and is observed in neonatal, but not in adult rat cardiomyocytes."xsd:string |
| http://purl.uniprot.org/citations/31669265 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2019.118562"xsd:string |
| http://purl.uniprot.org/citations/31669265 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/31669265 | http://purl.uniprot.org/core/author | "Heim P."xsd:string |
| http://purl.uniprot.org/citations/31669265 | http://purl.uniprot.org/core/author | "Brink M."xsd:string |
| http://purl.uniprot.org/citations/31669265 | http://purl.uniprot.org/core/author | "Morandi C."xsd:string |
| http://purl.uniprot.org/citations/31669265 | http://purl.uniprot.org/core/author | "Montessuit C."xsd:string |
| http://purl.uniprot.org/citations/31669265 | http://purl.uniprot.org/core/author | "Brouwer G.R."xsd:string |
| http://purl.uniprot.org/citations/31669265 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31669265 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta Mol Cell Res"xsd:string |
| http://purl.uniprot.org/citations/31669265 | http://purl.uniprot.org/core/pages | "118562"xsd:string |
| http://purl.uniprot.org/citations/31669265 | http://purl.uniprot.org/core/title | "Neuregulin-1 triggers GLUT4 translocation and enhances glucose uptake independently of insulin receptor substrate and ErbB3 in neonatal rat cardiomyocytes."xsd:string |
| http://purl.uniprot.org/citations/31669265 | http://purl.uniprot.org/core/volume | "1867"xsd:string |
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