| http://purl.uniprot.org/citations/31672911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31672911 | http://www.w3.org/2000/01/rdf-schema#comment | "The cross-talk between the microbiota and the immune system plays a fundamental role in the control of host physiology. However, the tissue-specific factors controlling this dialogue remain poorly understood. Here we demonstrate that T cell responses to commensal colonization are associated with the development of organized cellular clusters within the skin epithelium. These organized lymphocyte clusters are surrounded by keratinocytes expressing a discrete program associated with antigen presentation and antimicrobial defense. Notably, IL-22-mediated keratinocyte-intrinsic MHC class II expression was required for the selective accumulation of commensal-induced IFN-γ, but not IL-17A-producing CD4+ T cells within the skin. Taking these data together, this work uncovers an unexpected role for MHC class II expression by keratinocytes in the control of homeostatic type 1 responses to the microbiota. Our findings have important implications for the understanding of the tissue-specific rules governing the dialogue between a host and its microbiota."xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1912432116"xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/author | "Lazarevic V."xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/author | "Rehermann B."xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/author | "Han S.J."xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/author | "Harrison O.J."xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/author | "Belkaid Y."xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/author | "Perez-Chaparro P.J."xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/author | "Rosshart S.P."xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/author | "Bouladoux N."xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/author | "Constantinides M.G."xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/author | "Linehan J.L."xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/author | "Tamoutounour S."xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/author | "Link V.M."xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/author | "Deckers J."xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/author | "Hurabielle C."xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/author | "Vujkovic-Cvijin I."xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/pages | "23643-23652"xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/title | "Keratinocyte-intrinsic MHCII expression controls microbiota-induced Th1 cell responses."xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://purl.uniprot.org/core/volume | "116"xsd:string |
| http://purl.uniprot.org/citations/31672911 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31672911 |
| http://purl.uniprot.org/citations/31672911 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31672911 |