| http://purl.uniprot.org/citations/31675497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31675497 | http://www.w3.org/2000/01/rdf-schema#comment | "Physical or mental stress leads to neuroplasticity in the brain and increases the risk of depression and anxiety. Stress exposure causes the dysfunction of peripheral T lymphocytes. However, the pathological role and underlying regulatory mechanism of peripheral T lymphocytes in mood disorders have not been well established. Here, we show that the lack of CD4+ T cells protects mice from stress-induced anxiety-like behavior. Physical stress-induced leukotriene B4 triggers severe mitochondrial fission in CD4+ T cells, which further leads to a variety of behavioral abnormalities including anxiety, depression, and social disorders. Metabolomic profiles and single-cell transcriptome reveal that CD4+ T cell-derived xanthine acts on oligodendrocytes in the left amygdala via adenosine receptor A1. Mitochondrial fission promotes the de novo synthesis of purine via interferon regulatory factor 1 accumulation in CD4+ T cells. Our study implicates a critical link between a purine metabolic disorder in CD4+ T cells and stress-driven anxiety-like behavior."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2019.10.001"xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Jin J."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Lu W."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Lu L."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Shen L."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Tong C."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Zhang L.'"xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Tang M."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Cao Q."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Wang H.L."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Feng X.H."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Zhong G."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Qian D.D."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Li Y.Y."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Ma X.Y."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Huang L.J."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Li Y.N."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Guo J.X."xsd:string |
| http://purl.uniprot.org/citations/31675497 | http://purl.uniprot.org/core/author | "Fan K.Q."xsd:string |