| http://purl.uniprot.org/citations/31676716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31676716 | http://www.w3.org/2000/01/rdf-schema#comment | "The kinetochore is essential for faithful chromosome segregation during mitosis. To form a functional kinetochore, constitutive centromere-associated network (CCAN) proteins are assembled on the centromere chromatin that contains the centromere-specific histone CENP-A. CENP-C, a CCAN protein, directly interacts with the CENP-A nucleosome to nucleate the kinetochore structure. As CENP-C is a hub protein for kinetochore assembly, it is critical to address how the CENP-A-CENP-C interaction is regulated during cell cycle progression. To address this question, we investigated the CENP-C C-terminal region, including a conserved CENP-A-binding motif, in both chicken and human cells and found that CDK1-mediated phosphorylation of CENP-C facilitates its binding to CENP-A in vitro and in vivo. We observed that CENP-A binding is involved in CENP-C kinetochore localization during mitosis. We also demonstrate that the CENP-A-CENP-C interaction is critical for long-term viability in human RPE-1 cells. These results provide deeper insights into protein-interaction network plasticity in centromere proteins during cell cycle progression."xsd:string |
| http://purl.uniprot.org/citations/31676716 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201907006"xsd:string |
| http://purl.uniprot.org/citations/31676716 | http://purl.uniprot.org/core/author | "Watanabe R."xsd:string |
| http://purl.uniprot.org/citations/31676716 | http://purl.uniprot.org/core/author | "Ariyoshi M."xsd:string |
| http://purl.uniprot.org/citations/31676716 | http://purl.uniprot.org/core/author | "Hara M."xsd:string |
| http://purl.uniprot.org/citations/31676716 | http://purl.uniprot.org/core/author | "Fukagawa T."xsd:string |
| http://purl.uniprot.org/citations/31676716 | http://purl.uniprot.org/core/author | "Fachinetti D."xsd:string |
| http://purl.uniprot.org/citations/31676716 | http://purl.uniprot.org/core/author | "Herve S."xsd:string |
| http://purl.uniprot.org/citations/31676716 | http://purl.uniprot.org/core/author | "Okumura E.I."xsd:string |
| http://purl.uniprot.org/citations/31676716 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31676716 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/31676716 | http://purl.uniprot.org/core/pages | "4042-4062"xsd:string |
| http://purl.uniprot.org/citations/31676716 | http://purl.uniprot.org/core/title | "CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and mitotic kinetochore localization."xsd:string |
| http://purl.uniprot.org/citations/31676716 | http://purl.uniprot.org/core/volume | "218"xsd:string |
| http://purl.uniprot.org/citations/31676716 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31676716 |
| http://purl.uniprot.org/citations/31676716 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31676716 |
| http://purl.uniprot.org/uniprot/#_Q03188-mappedCitation-31676716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31676716 |
| http://purl.uniprot.org/uniprot/#_P49450-mappedCitation-31676716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31676716 |
| http://purl.uniprot.org/uniprot/P49450 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31676716 |
| http://purl.uniprot.org/uniprot/Q03188 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31676716 |