| http://purl.uniprot.org/citations/31692106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31692106 | http://www.w3.org/2000/01/rdf-schema#comment | "Microglial cells are the immune cells of the brain that, by sensing the microenvironment, permit a correct brain development and function. They communicate with other glial cells and with neurons, releasing and responding to a number of molecules that exert effects on surrounding cells. Among these, neurotransmitters and, in particular, gamma-aminobutyric acid (GABA) has recently gained interest in this context. We demonstrated the expression of GABA transporter 1 (GAT-1) in microglial cells both in soma and cell processes. We show that microglial cell treatment with 1,2,5,6-tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride (NNC-711), a potent and selective GAT-1 inhibitor, significantly reduced Na+ -dependent GABA uptake. On the other hand, GABA uptake was significantly increased by cell treatment with (S)-1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-3-piperidinecarboxylic acid (SNAP-5114), a GAT-2/3 inhibitor, and this effect was completely blocked by the botulinum toxin BoNT/C1, that specifically cleaves and inactives syntaxin 1A (STX1A). Overall, these findings show that microglial cells express GAT-1 and indicate that STX1A plays an important role in the regulation of GAT-1-dependent GABA uptake in microglia."xsd:string |
| http://purl.uniprot.org/citations/31692106 | http://purl.org/dc/terms/identifier | "doi:10.1002/glia.23745"xsd:string |
| http://purl.uniprot.org/citations/31692106 | http://purl.uniprot.org/core/author | "Melone M."xsd:string |
| http://purl.uniprot.org/citations/31692106 | http://purl.uniprot.org/core/author | "Catalano M."xsd:string |
| http://purl.uniprot.org/citations/31692106 | http://purl.uniprot.org/core/author | "Fattorini G."xsd:string |
| http://purl.uniprot.org/citations/31692106 | http://purl.uniprot.org/core/author | "Conti F."xsd:string |
| http://purl.uniprot.org/citations/31692106 | http://purl.uniprot.org/core/author | "Limatola C."xsd:string |
| http://purl.uniprot.org/citations/31692106 | http://purl.uniprot.org/core/author | "Bassi S."xsd:string |
| http://purl.uniprot.org/citations/31692106 | http://purl.uniprot.org/core/author | "Serpe C."xsd:string |
| http://purl.uniprot.org/citations/31692106 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31692106 | http://purl.uniprot.org/core/name | "Glia"xsd:string |
| http://purl.uniprot.org/citations/31692106 | http://purl.uniprot.org/core/pages | "646-655"xsd:string |
| http://purl.uniprot.org/citations/31692106 | http://purl.uniprot.org/core/title | "Microglial expression of GAT-1 in the cerebral cortex."xsd:string |
| http://purl.uniprot.org/citations/31692106 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/31692106 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31692106 |
| http://purl.uniprot.org/citations/31692106 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31692106 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUA0-mappedCitation-31692106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31692106 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVF5-mappedCitation-31692106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31692106 |
| http://purl.uniprot.org/uniprot/#_A0A991EPK0-mappedCitation-31692106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31692106 |
| http://purl.uniprot.org/uniprot/#_O35526-mappedCitation-31692106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31692106 |
| http://purl.uniprot.org/uniprot/#_D6RFB9-mappedCitation-31692106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31692106 |
| http://purl.uniprot.org/uniprot/#_Q8BPL9-mappedCitation-31692106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31692106 |
| http://purl.uniprot.org/uniprot/#_Q8BR50-mappedCitation-31692106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31692106 |
| http://purl.uniprot.org/uniprot/#_Q8CBJ0-mappedCitation-31692106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31692106 |