| http://purl.uniprot.org/citations/31693903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31693903 | http://www.w3.org/2000/01/rdf-schema#comment | "The incidence of human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is increasing and implicated in more than 60% of all oropharyngeal carcinomas (OPSCCs). Although whole-genome, transcriptome, and proteome analyses have identified altered signaling pathways in HPV-induced HNSCCs, additional tools are needed to investigate the unique pathobiology of OPSCC. Herein, bioinformatics analyses of human HPV(+) HNSCCs revealed that all tumors express full-length E6 and identified molecular subtypes based on relative E6 and E7 expression levels. To recapitulate the levels, stoichiometric ratios, and anatomic location of E6/E7 expression, we generated a genetically engineered mouse model whereby balanced expression of E6/E7 is directed to the oropharyngeal epithelium. The addition of a mutant PIK3CAE545K allele leads to the rapid development of pre-malignant lesions marked by immune cell accumulation, and a subset of these lesions progress to OPSCC. This mouse provides a faithful immunocompetent model for testing treatments and investigating mechanisms of immunosuppression."xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2019.10.005"xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/author | "Montgomery S.A."xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/author | "Parker J.S."xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/author | "Cleveland J.L."xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/author | "Hayes D.N."xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/author | "Williams S.E."xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/author | "Kissil J.L."xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/author | "Parag-Sharma K."xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/author | "Henry E.C."xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/author | "Wagner B.L."xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/author | "Troutman S."xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/author | "Amelio A.L."xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/author | "Selitsky S.R."xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/author | "Byrd K.M."xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/author | "Carper M.B."xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/pages | "1660-1674.e7"xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/title | "An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma."xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/31693903 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31693903 |
| http://purl.uniprot.org/citations/31693903 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31693903 |