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http://purl.uniprot.org/citations/31701262http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31701262http://www.w3.org/2000/01/rdf-schema#comment"

Background

DnaJ/Hsp40 homolog, subfamily B, member 6 (DNAJB6) is significantly down-regulated in esophageal squamous cell carcinoma (ESCC), while its complicated molecular mechanisms are still unknown.

Aims

To investigate the relationship between DNAJB6 and ESCC.

Methods

The expression of DNAJB6 was detected in ESCC patient by Western blot and immunohistochemistry. To overexpress DNAJB6a by lentivirus infection, colony-forming, CCK-8, transwell, mouse xenograft assays were utilized to verify the proliferous, invasive, and migratory role of DNAJB6a in ESCC cells. The MDA and GSH assays determine whether DNAJB6a participates in cell redox reaction. The variation of AKT and GPX4 was detected by Western blot.

Results

The correlation between DNAJB6 level and lymph node metastasis in ESCC patient was negative. Overexpressing DNAJB6a shows tumor-suppressive effects in vitro and in vivo. In addition, DNAJB6a overexpression was accompanied together with a remarkable reduction in the protein levels of GPX4 and phosphorylated AKT (p-AKT).

Conclusion

DNAJB6 plays an important anti-oncogenic role in ESCC evolvement via ferroptosis."xsd:string
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http://purl.uniprot.org/citations/31701262http://purl.uniprot.org/core/author"Jiang B."xsd:string
http://purl.uniprot.org/citations/31701262http://purl.uniprot.org/core/author"Liu X."xsd:string
http://purl.uniprot.org/citations/31701262http://purl.uniprot.org/core/author"Fang Z."xsd:string
http://purl.uniprot.org/citations/31701262http://purl.uniprot.org/core/author"Song X."xsd:string
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http://purl.uniprot.org/citations/31701262http://purl.uniprot.org/core/author"Wang Q."xsd:string
http://purl.uniprot.org/citations/31701262http://purl.uniprot.org/core/author"Shi M."xsd:string
http://purl.uniprot.org/citations/31701262http://purl.uniprot.org/core/author"Wu S."xsd:string
http://purl.uniprot.org/citations/31701262http://purl.uniprot.org/core/author"Zhao Y."xsd:string
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http://purl.uniprot.org/citations/31701262http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/31701262http://purl.uniprot.org/core/name"Dig Dis Sci"xsd:string
http://purl.uniprot.org/citations/31701262http://purl.uniprot.org/core/pages"1999-2008"xsd:string
http://purl.uniprot.org/citations/31701262http://purl.uniprot.org/core/title"DNAJB6 Promotes Ferroptosis in Esophageal Squamous Cell Carcinoma."xsd:string
http://purl.uniprot.org/citations/31701262http://purl.uniprot.org/core/volume"65"xsd:string
http://purl.uniprot.org/citations/31701262http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31701262
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