| http://purl.uniprot.org/citations/31712603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31712603 | http://www.w3.org/2000/01/rdf-schema#comment | "The Epithelial to Mesenchymal Transition (EMT) regulates cell plasticity during embryonic development and in disease. It is dynamically orchestrated by transcription factors (EMT-TFs), including Snail, Zeb, Twist and Prrx, all activated by TGF-β among other signals. Here we find that Snail1 and Prrx1, which respectively associate with gain or loss of stem-like properties and with bad or good prognosis in cancer patients, are expressed in complementary patterns during vertebrate development and in cancer. We show that this complementarity is established through a feedback loop in which Snail1 directly represses Prrx1, and Prrx1, through direct activation of the miR-15 family, attenuates the expression of Snail1. We also describe how this gene regulatory network can establish a hierarchical temporal expression of Snail1 and Prrx1 during EMT and validate its existence in vitro and in vivo, providing a mechanism to switch and select different EMT programs with important implications in development and disease."xsd:string |
| http://purl.uniprot.org/citations/31712603 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-13091-8"xsd:string |
| http://purl.uniprot.org/citations/31712603 | http://purl.uniprot.org/core/author | "Galceran J."xsd:string |
| http://purl.uniprot.org/citations/31712603 | http://purl.uniprot.org/core/author | "Nieto M.A."xsd:string |
| http://purl.uniprot.org/citations/31712603 | http://purl.uniprot.org/core/author | "Arcas A."xsd:string |
| http://purl.uniprot.org/citations/31712603 | http://purl.uniprot.org/core/author | "Ocana O.H."xsd:string |
| http://purl.uniprot.org/citations/31712603 | http://purl.uniprot.org/core/author | "Rago L."xsd:string |
| http://purl.uniprot.org/citations/31712603 | http://purl.uniprot.org/core/author | "Fazilaty H."xsd:string |
| http://purl.uniprot.org/citations/31712603 | http://purl.uniprot.org/core/author | "Garcia-Asencio F."xsd:string |
| http://purl.uniprot.org/citations/31712603 | http://purl.uniprot.org/core/author | "Kass Youssef K."xsd:string |
| http://purl.uniprot.org/citations/31712603 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31712603 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/31712603 | http://purl.uniprot.org/core/pages | "5115"xsd:string |
| http://purl.uniprot.org/citations/31712603 | http://purl.uniprot.org/core/title | "A gene regulatory network to control EMT programs in development and disease."xsd:string |
| http://purl.uniprot.org/citations/31712603 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/31712603 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31712603 |
| http://purl.uniprot.org/citations/31712603 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31712603 |
| http://purl.uniprot.org/uniprot/#_P63013-mappedCitation-31712603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31712603 |
| http://purl.uniprot.org/uniprot/#_G3UZ44-mappedCitation-31712603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31712603 |
| http://purl.uniprot.org/uniprot/#_Q02085-mappedCitation-31712603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31712603 |
| http://purl.uniprot.org/uniprot/#_Q4FK48-mappedCitation-31712603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31712603 |
| http://purl.uniprot.org/uniprot/#_Q8BGB1-mappedCitation-31712603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31712603 |
| http://purl.uniprot.org/uniprot/#_Q3TMI4-mappedCitation-31712603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31712603 |
| http://purl.uniprot.org/uniprot/#_Q9D861-mappedCitation-31712603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31712603 |