| http://purl.uniprot.org/citations/31719149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31719149 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic recurrent multifocal osteomyelitis (CRMO) in humans can be modeled in Pstpip2cmo mice, which carry a missense mutation in the proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2) gene. As cmo disease in mice, the experimental model analogous to human CRMO, is mediated specifically by IL-1β and not by IL-1α, delineating the molecular pathways contributing to pathogenic IL-1β production is crucial to developing targeted therapies. In particular, our earlier findings support redundant roles of NLR family pyrin domain-containing 3 (NLRP3) and caspase-1 with caspase-8 in instigating cmo However, the signaling components upstream of caspase-8 and pro-IL-1β cleavage in Pstpip2cmo mice are not well-understood. Therefore, here we investigated the signaling pathways in these mice and discovered a central role of a nonreceptor tyrosine kinase, spleen tyrosine kinase (SYK), in mediating osteomyelitis. Using several mutant mouse strains, immunoblotting, and microcomputed tomography, we demonstrate that absent in melanoma 2 (AIM2), receptor-interacting serine/ threonine protein kinase 3 (RIPK3), and caspase recruitment domain-containing protein 9 (CARD9) are each dispensable for osteomyelitis induction in Pstpip2cmo mice, whereas genetic deletion of Syk completely abrogates the disease phenotype. We further show that SYK centrally mediates signaling upstream of caspase-1 and caspase-8 activation and principally up-regulates NF-κB and IL-1β signaling in Pstpip2cmo mice, thereby inducing cmo These results provide a rationale for directly targeting SYK and its downstream signaling components in CRMO."xsd:string |
| http://purl.uniprot.org/citations/31719149 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.ra119.010623"xsd:string |
| http://purl.uniprot.org/citations/31719149 | http://purl.uniprot.org/core/author | "Kanneganti T.D."xsd:string |
| http://purl.uniprot.org/citations/31719149 | http://purl.uniprot.org/core/author | "Burton A."xsd:string |
| http://purl.uniprot.org/citations/31719149 | http://purl.uniprot.org/core/author | "Gurung P."xsd:string |
| http://purl.uniprot.org/citations/31719149 | http://purl.uniprot.org/core/author | "Karki R."xsd:string |
| http://purl.uniprot.org/citations/31719149 | http://purl.uniprot.org/core/author | "Sharma B.R."xsd:string |
| http://purl.uniprot.org/citations/31719149 | http://purl.uniprot.org/core/author | "Geiger R."xsd:string |
| http://purl.uniprot.org/citations/31719149 | http://purl.uniprot.org/core/author | "Banoth B."xsd:string |
| http://purl.uniprot.org/citations/31719149 | http://purl.uniprot.org/core/author | "Dasari T.K."xsd:string |
| http://purl.uniprot.org/citations/31719149 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31719149 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/31719149 | http://purl.uniprot.org/core/pages | "3394-3400"xsd:string |
| http://purl.uniprot.org/citations/31719149 | http://purl.uniprot.org/core/title | "The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis."xsd:string |
| http://purl.uniprot.org/citations/31719149 | http://purl.uniprot.org/core/volume | "295"xsd:string |
| http://purl.uniprot.org/citations/31719149 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31719149 |
| http://purl.uniprot.org/citations/31719149 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31719149 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-31719149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31719149 |
| http://purl.uniprot.org/uniprot/#_A0A087WQT6-mappedCitation-31719149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31719149 |
| http://purl.uniprot.org/uniprot/#_E9PZP3-mappedCitation-31719149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31719149 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPT3-mappedCitation-31719149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31719149 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQW9-mappedCitation-31719149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31719149 |
| http://purl.uniprot.org/uniprot/#_A0A494BAM6-mappedCitation-31719149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31719149 |
| http://purl.uniprot.org/uniprot/#_A2AIV8-mappedCitation-31719149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31719149 |