| http://purl.uniprot.org/citations/31722792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31722792 | http://www.w3.org/2000/01/rdf-schema#comment | "RNA binding protein HuD regulates translation and turnover of target mRNAs, thereby affecting gene expression at the posttranscriptional level in mainly neuronal as well as pancreatic β-cells. Here, we identified insulinoma-associated 1 (INSM1), an essential factor governing differentiation and proliferation of neuroendocrine cells, as a novel target of HuD and demonstrated the regulatory mechanism of INSM1 expression by HuD. HuD bound to 3'untranslated region (3'UTR) of Insm1 mRNA and negatively regulated its expression; knockdown of HuD increased INSM1 expression, while HuD overexpression repressed it by destabilizing its mRNA. In addition, we further demonstrated that HuD enhanced reduction of INSM1 by miR-203a, a novel miRNA targeting Insm1 mRNA 3'UTR. These results suggest that HuD and miR-203a cooperatively regulate INSM1 expression and it provides a novel regulatory mechanism of INSM1 expression by HuD and miR-203a."xsd:string |
| http://purl.uniprot.org/citations/31722792 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2019.11.030"xsd:string |
| http://purl.uniprot.org/citations/31722792 | http://purl.uniprot.org/core/author | "Lee E.K."xsd:string |
| http://purl.uniprot.org/citations/31722792 | http://purl.uniprot.org/core/author | "Kim C."xsd:string |
| http://purl.uniprot.org/citations/31722792 | http://purl.uniprot.org/core/author | "Ahn S."xsd:string |
| http://purl.uniprot.org/citations/31722792 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31722792 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/31722792 | http://purl.uniprot.org/core/pages | "971-976"xsd:string |
| http://purl.uniprot.org/citations/31722792 | http://purl.uniprot.org/core/title | "RNA binding protein HuD and microRNA-203a cooperatively regulate insulinoma-associated 1 mRNA."xsd:string |
| http://purl.uniprot.org/citations/31722792 | http://purl.uniprot.org/core/volume | "521"xsd:string |
| http://purl.uniprot.org/citations/31722792 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31722792 |
| http://purl.uniprot.org/citations/31722792 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31722792 |
| http://purl.uniprot.org/uniprot/#_Q1KS26-mappedCitation-31722792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31722792 |
| http://purl.uniprot.org/uniprot/#_J7H3M8-mappedCitation-31722792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31722792 |
| http://purl.uniprot.org/uniprot/#_Q1W5D4-mappedCitation-31722792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31722792 |
| http://purl.uniprot.org/uniprot/#_Q05BD7-mappedCitation-31722792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31722792 |
| http://purl.uniprot.org/uniprot/#_Q80XH9-mappedCitation-31722792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31722792 |
| http://purl.uniprot.org/uniprot/#_Q63ZV0-mappedCitation-31722792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31722792 |
| http://purl.uniprot.org/uniprot/#_Q9CXQ0-mappedCitation-31722792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31722792 |
| http://purl.uniprot.org/uniprot/#_Q61701-mappedCitation-31722792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31722792 |
| http://purl.uniprot.org/uniprot/J7H3M8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31722792 |
| http://purl.uniprot.org/uniprot/Q9CXQ0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31722792 |
| http://purl.uniprot.org/uniprot/Q61701 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31722792 |
| http://purl.uniprot.org/uniprot/Q1W5D4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31722792 |