| http://purl.uniprot.org/citations/31723262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31723262 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspase-8 is a protease with both pro-death and pro-survival functions: it mediates apoptosis induced by death receptors such as TNFR11, and suppresses necroptosis mediated by the kinase RIPK3 and the pseudokinase MLKL2-4. Mice that lack caspase-8 display MLKL-dependent embryonic lethality4, as do mice that express catalytically inactive CASP8(C362A)5. Casp8C362A/C362AMlkl-/- mice die during the perinatal period5, whereas Casp8-/-Mlkl-/- mice are viable4, which indicates that inactive caspase-8 also has a pro-death scaffolding function. Here we show that mutant CASP8(C362A) induces the formation of ASC (also known as PYCARD) specks, and caspase-1-dependent cleavage of GSDMD and caspases 3 and 7 in MLKL-deficient mouse intestines around embryonic day 18. Caspase-1 and its adaptor ASC contributed to the perinatal lethal phenotype because a number of Casp8C362A/C362AMlkl-/-Casp1-/- and Casp8C362A/C362AMlkl-/-Asc-/- mice survived beyond weaning. Transfection studies suggest that inactive caspase-8 adopts a distinct conformation to active caspase-8, enabling its prodomain to engage ASC. Upregulation of the lipopolysaccharide sensor caspase-11 in the intestines of both Casp8C362A/C362AMlkl-/- and Casp8C362A/C362AMlkl-/-Casp1-/- mice also contributed to lethality because Casp8C362A/C362AMlkl-/-Casp1-/-Casp11-/- (Casp11 is also known as Casp4) neonates survived more often than Casp8C362A/C362AMlkl-/-Casp1-/- neonates. Finally, Casp8C362A/C362ARipk3-/-Casp1-/-Casp11-/- mice survived longer than Casp8C362A/C362AMlkl-/-Casp1-/-Casp11-/- mice, indicating that a necroptosis-independent function of RIPK3 also contributes to lethality. Thus, unanticipated plasticity in death pathways is revealed when caspase-8-dependent apoptosis and MLKL-dependent necroptosis are inhibited."xsd:string |
| http://purl.uniprot.org/citations/31723262 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-019-1752-8"xsd:string |
| http://purl.uniprot.org/citations/31723262 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/31723262 | http://purl.uniprot.org/core/author | "Roose-Girma M."xsd:string |
| http://purl.uniprot.org/citations/31723262 | http://purl.uniprot.org/core/author | "Sagolla M.S."xsd:string |
| http://purl.uniprot.org/citations/31723262 | http://purl.uniprot.org/core/author | "Dixit V.M."xsd:string |
| http://purl.uniprot.org/citations/31723262 | http://purl.uniprot.org/core/author | "Modrusan Z."xsd:string |
| http://purl.uniprot.org/citations/31723262 | http://purl.uniprot.org/core/author | "Newton K."xsd:string |
| http://purl.uniprot.org/citations/31723262 | http://purl.uniprot.org/core/author | "Dugger D.L."xsd:string |
| http://purl.uniprot.org/citations/31723262 | http://purl.uniprot.org/core/author | "Maltzman A."xsd:string |
| http://purl.uniprot.org/citations/31723262 | http://purl.uniprot.org/core/author | "Reja R."xsd:string |
| http://purl.uniprot.org/citations/31723262 | http://purl.uniprot.org/core/author | "Webster J.D."xsd:string |
| http://purl.uniprot.org/citations/31723262 | http://purl.uniprot.org/core/author | "Wickliffe K.E."xsd:string |
| http://purl.uniprot.org/citations/31723262 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31723262 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/31723262 | http://purl.uniprot.org/core/pages | "679-682"xsd:string |
| http://purl.uniprot.org/citations/31723262 | http://purl.uniprot.org/core/title | "Activity of caspase-8 determines plasticity between cell death pathways."xsd:string |
| http://purl.uniprot.org/citations/31723262 | http://purl.uniprot.org/core/volume | "575"xsd:string |
| http://purl.uniprot.org/citations/31723262 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31723262 |
| http://purl.uniprot.org/citations/31723262 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31723262 |
| http://purl.uniprot.org/uniprot/#_A0A087WQT6-mappedCitation-31723262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31723262 |
| http://purl.uniprot.org/uniprot/#_E0CY92-mappedCitation-31723262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31723262 |
| http://purl.uniprot.org/uniprot/#_E9PZP3-mappedCitation-31723262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31723262 |
| http://purl.uniprot.org/uniprot/#_P70677-mappedCitation-31723262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31723262 |