| http://purl.uniprot.org/citations/31726679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31726679 | http://www.w3.org/2000/01/rdf-schema#comment | "Claudin-2 is expressed in the tight junctions of leaky epithelia, where it forms cation-selective and water permeable paracellular channels. Its abundance is under fine control by a complex signaling network that affects both its synthesis and turnover in response to various environmental inputs. Claudin-2 expression is dysregulated in many pathologies including cancer, inflammation, and fibrosis. Claudin-2 has a key role in energy-efficient ion and water transport in the proximal tubules of the kidneys and in the gut. Importantly, strong evidence now also supports a role for this protein as a modulator of vital cellular events relevant to diseases. Signaling pathways that are overactivated in diseases can alter claudin-2 expression, and a good correlation exists between disease stage and claudin-2 abundance. Further, loss- and gain-of-function studies showed that primary changes in claudin-2 expression impact vital cellular processes such as proliferation, migration, and cell fate determination. These effects appear to be mediated by alterations in key signaling pathways. The specific mechanisms linking claudin-2 to these changes remain poorly understood, but adapters binding to the intracellular portion of claudin-2 may play a key role. Thus, dysregulation of claudin-2 may contribute to the generation, maintenance, and/or progression of diseases through both permeability-dependent and -independent mechanisms. The aim of this review is to provide an overview of the properties, regulation, and functions of claudin-2, with a special emphasis on its signal-modulating effects and possible role in diseases."xsd:string |
| http://purl.uniprot.org/citations/31726679 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms20225655"xsd:string |
| http://purl.uniprot.org/citations/31726679 | http://purl.uniprot.org/core/author | "Venugopal S."xsd:string |
| http://purl.uniprot.org/citations/31726679 | http://purl.uniprot.org/core/author | "Szaszi K."xsd:string |
| http://purl.uniprot.org/citations/31726679 | http://purl.uniprot.org/core/author | "Anwer S."xsd:string |
| http://purl.uniprot.org/citations/31726679 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31726679 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/31726679 | http://purl.uniprot.org/core/pages | "E5655"xsd:string |
| http://purl.uniprot.org/citations/31726679 | http://purl.uniprot.org/core/title | "Claudin-2: Roles beyond Permeability Functions."xsd:string |
| http://purl.uniprot.org/citations/31726679 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/31726679 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31726679 |
| http://purl.uniprot.org/citations/31726679 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31726679 |
| http://purl.uniprot.org/uniprot/#_P57739-mappedCitation-31726679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31726679 |
| http://purl.uniprot.org/uniprot/P57739 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31726679 |