| http://purl.uniprot.org/citations/31729060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31729060 | http://www.w3.org/2000/01/rdf-schema#comment | "Mesenchymal epithelial transition (C-MET) factor overexpression has been found in many types of cancer and has served as an important molecular target for therapeutic intervention. However, the role of C-MET in retinoblastoma remains largely unclear. The present study aimed to investigate the potential role and mechanism of C-MET in Y79 retinoblastoma cells. We found that C-MET was highly expressed in Y79 retinoblastoma cells, and, in addition, the levels of C-MET were positively correlated with cell proliferation and retinoblastoma growth. Inhibition of C-MET suppressed Y79 retinoblastoma cell proliferation and tumour growth. Mechanistically, we showed that HGF-induced C-MET-dependent signal transduction resulted in ERK 1/2 phosphorylation, which subsequently promoted the nuclear translocation of PKM2. Nuclear PKM2 further interacted with histone H3 and contributed to C-MET-dependent cyclin D1 and c-Myc expression and cell proliferation. These findings highlight the role of C-MET in Y79 retinoblastoma cells and reveal a C-MET-dependent signal transduction mechanism. C-MET may be a potential therapeutic target for retinoblastoma. SIGNIFICANCE OF THE STUDY: We demonstrated a new target of retinoblastoma, C-MET. C-MET-dependent signal transduction promotes Y79 retinoblastoma cell proliferation and tumour growth through ERK 1/2/PKM2/histone H3 signalling pathway. C-MET may be a potential target for retinoblastoma therapy."xsd:string |
| http://purl.uniprot.org/citations/31729060 | http://purl.org/dc/terms/identifier | "doi:10.1002/cbf.3464"xsd:string |
| http://purl.uniprot.org/citations/31729060 | http://purl.uniprot.org/core/author | "Luo H."xsd:string |
| http://purl.uniprot.org/citations/31729060 | http://purl.uniprot.org/core/author | "Zeng W."xsd:string |
| http://purl.uniprot.org/citations/31729060 | http://purl.uniprot.org/core/author | "Dai H."xsd:string |
| http://purl.uniprot.org/citations/31729060 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31729060 | http://purl.uniprot.org/core/name | "Cell Biochem Funct"xsd:string |
| http://purl.uniprot.org/citations/31729060 | http://purl.uniprot.org/core/pages | "204-212"xsd:string |
| http://purl.uniprot.org/citations/31729060 | http://purl.uniprot.org/core/title | "C-MET-dependent signal transduction mediates retinoblastoma growth by regulating PKM2 nuclear translocation."xsd:string |
| http://purl.uniprot.org/citations/31729060 | http://purl.uniprot.org/core/volume | "38"xsd:string |
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