| http://purl.uniprot.org/citations/31730657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31730657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31730657 | http://www.w3.org/2000/01/rdf-schema#comment | "Gene expression involves the transcription and splicing of nascent transcripts through the removal of introns. In Drosophila, a double-stranded RNA binding protein Disco-interacting protein 1 (DIP1) targets INE-1 stable intronic sequence RNAs (sisRNAs) for degradation after splicing. How nascent transcripts that also contain INE-1 sequences escape degradation remains unknown. Here we observe that these nascent transcripts can also be bound by DIP1 but the Drosophila homolog of SON (Dsn) protects them from unproductive degradation in ovaries. Dsn localizes to the satellite body where active decay of INE-1 sisRNAs by DIP1 occurs. Dsn is a repressor of DIP1 posttranslational modifications (primarily sumoylation) that are assumed to be required for efficient DIP1 activity. Moreover, the pre-mRNA destabilization caused by Dsn depletion is rescued in DIP1 or Sumo heterozygous mutants, suggesting that Dsn is a negative regulator of DIP1. Our results reveal that under normal circumstances nascent transcripts are susceptible to DIP1-mediated degradation, however intronic sequences are protected by Dsn until intron excision has taken place."xsd:string |
| http://purl.uniprot.org/citations/31730657 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1008498"xsd:string |
| http://purl.uniprot.org/citations/31730657 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1008498"xsd:string |
| http://purl.uniprot.org/citations/31730657 | http://purl.uniprot.org/core/author | "Pek J.W."xsd:string |
| http://purl.uniprot.org/citations/31730657 | http://purl.uniprot.org/core/author | "Pek J.W."xsd:string |
| http://purl.uniprot.org/citations/31730657 | http://purl.uniprot.org/core/author | "Tay M.L."xsd:string |
| http://purl.uniprot.org/citations/31730657 | http://purl.uniprot.org/core/author | "Tay M.L."xsd:string |
| http://purl.uniprot.org/citations/31730657 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31730657 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31730657 | http://purl.uniprot.org/core/name | "PLoS Genet."xsd:string |
| http://purl.uniprot.org/citations/31730657 | http://purl.uniprot.org/core/name | "PLoS Genet."xsd:string |
| http://purl.uniprot.org/citations/31730657 | http://purl.uniprot.org/core/pages | "E1008498"xsd:string |
| http://purl.uniprot.org/citations/31730657 | http://purl.uniprot.org/core/pages | "E1008498"xsd:string |
| http://purl.uniprot.org/citations/31730657 | http://purl.uniprot.org/core/title | "SON protects nascent transcripts from unproductive degradation by counteracting DIP1."xsd:string |
| http://purl.uniprot.org/citations/31730657 | http://purl.uniprot.org/core/title | "SON protects nascent transcripts from unproductive degradation by counteracting DIP1."xsd:string |
| http://purl.uniprot.org/citations/31730657 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/31730657 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/31730657 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31730657 |
| http://purl.uniprot.org/citations/31730657 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31730657 |
| http://purl.uniprot.org/citations/31730657 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31730657 |
| http://purl.uniprot.org/citations/31730657 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31730657 |
| http://purl.uniprot.org/uniprot/Q9VHB0 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/31730657 |
| http://purl.uniprot.org/uniprot/Q9VHB0#attribution-053BD695860E06E6F455834F8B0320B3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/31730657 |