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http://purl.uniprot.org/citations/31734756http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/31734756http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

The sFlt-1 (soluble fms-like tyrosine kinase-1)/PlGF (placental growth factor) ratio and uterine artery Doppler have shown to be helpful in the diagnosis of pre-eclampsia (PE). The predictive value of the cerebroplacental ratio (CPR) regarding adverse perinatal outcome (APO) in low-risk pregnancies is intensively discussed. We evaluated the extent to which sFlt-1/PlGF ratio and feto-maternal Doppler may be useful in predicting APO in singleton pregnancies complicated by late-onset PE and/or HELLP syndrome.

Methods

This is a retrospective study from 2010 to 2018 consisting of singleton pregnancies with confirmed diagnosis of late-onset (lo ≥ 34 weeks) PE/HELLP syndrome in which sFlt-1/PlGF ratio and feto-maternal Doppler (mUtA-PI: mean uterine artery pulsatility index and CPR) were determined. The ability of sFlt-1/PlGF ratio, mUtA-PI, CPR and their combination to predict APO or SGA was evaluated using receiver operating characteristic (ROC) curves.

Results

67 patients were included in the final analysis. Of these, sFlt-1/PlGF was > 110 (defining angiogenic lo PE) in 40.3% (27/67), mUtA-PI was above the 95th centile in 34.3% (23/67) patients and CPR was lower than the 5th centile in 10.4% (7/67). Abnormal sFlt-1/PlGF and mUtA-PI as well as CPR were associated with a lower birth weight (BW). Late-preterm birth (< 37 weeks) as well as postnatal diagnosis of small for gestational age (SGA: BW < 3rd centile) was significantly more often in angiogenic lo PE cases. Neither sFlt-1/PIGF nor CPR or mUtA-PI were APO predictors. Only for sFlt-1/PlGF, ROC analysis revealed a significant predictive value for postnatal SGA (AUC = 0.856, p = 0.001, 95% CI 0.75-0.97). There was no statistical added value of combined SGA predictors as compared to sFlt-1/PlGF alone.

Conclusions

In patients with lo PE, adding sFlt-1/PlGF ratio to routine antepartum fetal surveillance may be useful to identify cases of postnatal SGA. However, further prospective studies are warranted to define the role of feto-maternal Doppler and sFlt-1/PlGF ratio as outcome predictors."xsd:string
http://purl.uniprot.org/citations/31734756http://purl.org/dc/terms/identifier"doi:10.1007/s00404-019-05365-9"xsd:string
http://purl.uniprot.org/citations/31734756http://purl.uniprot.org/core/author"Seiler A."xsd:string
http://purl.uniprot.org/citations/31734756http://purl.uniprot.org/core/author"Abel K."xsd:string
http://purl.uniprot.org/citations/31734756http://purl.uniprot.org/core/author"Kuschel B."xsd:string
http://purl.uniprot.org/citations/31734756http://purl.uniprot.org/core/author"Axt-Fliedner R."xsd:string
http://purl.uniprot.org/citations/31734756http://purl.uniprot.org/core/author"Haller B."xsd:string
http://purl.uniprot.org/citations/31734756http://purl.uniprot.org/core/author"Lobmaier S.M."xsd:string
http://purl.uniprot.org/citations/31734756http://purl.uniprot.org/core/author"Ortiz J.U."xsd:string
http://purl.uniprot.org/citations/31734756http://purl.uniprot.org/core/author"Enzensberger C."xsd:string
http://purl.uniprot.org/citations/31734756http://purl.uniprot.org/core/author"Flechsenhar S."xsd:string
http://purl.uniprot.org/citations/31734756http://purl.uniprot.org/core/author"Graupner O."xsd:string
http://purl.uniprot.org/citations/31734756http://purl.uniprot.org/core/author"Karge A."xsd:string
http://purl.uniprot.org/citations/31734756http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/31734756http://purl.uniprot.org/core/name"Arch Gynecol Obstet"xsd:string
http://purl.uniprot.org/citations/31734756http://purl.uniprot.org/core/pages"375-385"xsd:string
http://purl.uniprot.org/citations/31734756http://purl.uniprot.org/core/title"Role of sFlt-1/PlGF ratio and feto-maternal Doppler for the prediction of adverse perinatal outcome in late-onset pre-eclampsia."xsd:string
http://purl.uniprot.org/citations/31734756http://purl.uniprot.org/core/volume"301"xsd:string
http://purl.uniprot.org/citations/31734756http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/31734756
http://purl.uniprot.org/citations/31734756http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/31734756
http://purl.uniprot.org/uniprot/#_H9N1E7-mappedCitation-31734756http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31734756
http://purl.uniprot.org/uniprot/#_H9N1E8-mappedCitation-31734756http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31734756
http://purl.uniprot.org/uniprot/#_B5A924-mappedCitation-31734756http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31734756
http://purl.uniprot.org/uniprot/#_B1AC84-mappedCitation-31734756http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/31734756
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