| http://purl.uniprot.org/citations/31742248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31742248 | http://www.w3.org/2000/01/rdf-schema#comment | "Catecholamines stimulate the first step of lipolysis by PKA-dependent release of the lipid droplet-associated protein ABHD5 from perilipin to co-activate the lipase ATGL. Here, we unmask a yet unrecognized proteolytic and cardioprotective function of ABHD5. ABHD5 acts in vivo and in vitro as a serine protease cleaving HDAC4. Through the production of an N-terminal polypeptide of HDAC4 (HDAC4-NT), ABHD5 inhibits MEF2-dependent gene expression and thereby controls glucose handling. ABHD5-deficiency leads to neutral lipid storage disease in mice. Cardiac-specific gene therapy of HDAC4-NT does not protect from intra-cardiomyocyte lipid accumulation but strikingly from heart failure, thereby challenging the concept of lipotoxicity-induced heart failure. ABHD5 levels are reduced in failing human hearts and murine transgenic ABHD5 expression protects from pressure-overload induced heart failure. These findings represent a conceptual advance by connecting lipid with glucose metabolism through HDAC4 proteolysis and enable new translational approaches to treat cardiometabolic disease."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.org/dc/terms/identifier | "doi:10.1038/s42255-019-0138-4"xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Xu C."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Grone H.J."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Moro C."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Haemmerle G."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Katus H.A."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Backs J."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Dieterich C."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Oberer M."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Fischer T."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Most P."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Gong X.M."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Sossalla S."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Sauer S.W."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Lehmann L.H."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Tyedmers J."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Federico G."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Muller O.J."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Worst B.C."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Dewenter M."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Jebessa Z.H."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Wechselberger L."xsd:string |
| http://purl.uniprot.org/citations/31742248 | http://purl.uniprot.org/core/author | "Schreiter F."xsd:string |