| http://purl.uniprot.org/citations/31742717 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31742717 | http://www.w3.org/2000/01/rdf-schema#comment | "In previous studies, carried out in humans, we showed that females are resistant to Leishmania mexicana infection. We also showed that 17β-estradiol (E2) induces killing of parasites inside of murine macrophages. In this work, we compared, for the first time, L mexicana survival inside of male (male BMDM) and female (female BMDM) bone marrow-derived macrophages (BMDM) treated in vitro with E2 or dihydrotestosterone (DHT). We also compared their levels of nitric oxide (NO), interleukin (IL)-6, IL-10, IL-12p70 and tumour necrosis factor (TNF-α). We found that female BMDM are a lot less susceptible to infection as compared with male BMDM. 17β-estradiol induced killing of most parasites inside of female BMDM. Dihydrotestosterone, on the other hand, induced some parasite killing inside of some infected male BMDM. Interleukin-6 levels were higher in female BMDM treated with either hormone. Neither TNF-α nor IL-10 levels showed significant differences compared with sham controls. Interestingly IL-12p70 was more abundantly produced by sham female BMDM as compared with sham male BMDM. Only female BMDM treated with E2 trigger a robust IL-12p70 production, but it was significantly reduced in male BMDM. This suggests IL-12p70 is an important factor in female-macrophage resistance to L mexicana parasites."xsd:string |
| http://purl.uniprot.org/citations/31742717 | http://purl.org/dc/terms/identifier | "doi:10.1111/pim.12685"xsd:string |
| http://purl.uniprot.org/citations/31742717 | http://purl.uniprot.org/core/author | "Lezama-Davila C.M."xsd:string |
| http://purl.uniprot.org/citations/31742717 | http://purl.uniprot.org/core/author | "Isaac-Marquez A.P."xsd:string |
| http://purl.uniprot.org/citations/31742717 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31742717 | http://purl.uniprot.org/core/name | "Parasite Immunol"xsd:string |
| http://purl.uniprot.org/citations/31742717 | http://purl.uniprot.org/core/pages | "e12685"xsd:string |
| http://purl.uniprot.org/citations/31742717 | http://purl.uniprot.org/core/title | "Cytokine regulation of female-macrophage resistance to Leishmania mexicana parasites. Role of IL-12p70."xsd:string |
| http://purl.uniprot.org/citations/31742717 | http://purl.uniprot.org/core/volume | "42"xsd:string |
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