| http://purl.uniprot.org/citations/31746185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31746185 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription factor 19 (TCF19) plays critical roles in type 1 diabetes and the maintenance of pancreatic β cells. Recent studies have also implicated TCF19 in cell proliferation of hepatic carcinoma and non-small cell lung carcinoma; however, the mechanism underlying this regulation remains elusive. At the molecular level, TCF19 contains two modules, the plant homeodomain (PHD) finger and the forkhead-associated (FHA) domain, of unclear function. Here, we show that TCF19 mediates hepatocellular carcinoma HepG2 cell proliferation through its PHD finger that recognizes trimethylated lysine 4 of histone 3 (H3K4me3). W316 of the PHD finger of TCF19 is one of the critical residues eliciting this function. Whole genome microarray analysis and orthogonal cell-based assays identified a large subset of genes involved in cell survival and proliferation that depend on TCF19. Our data suggest that TCF19 acts as a pro-oncogene in hepatocellular carcinoma cells and that its functional PHD finger is critical in cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/31746185 | http://purl.org/dc/terms/identifier | "doi:10.1021/acs.biochem.9b00771"xsd:string |
| http://purl.uniprot.org/citations/31746185 | http://purl.uniprot.org/core/author | "Roy S."xsd:string |
| http://purl.uniprot.org/citations/31746185 | http://purl.uniprot.org/core/author | "Klein B.J."xsd:string |
| http://purl.uniprot.org/citations/31746185 | http://purl.uniprot.org/core/author | "Sen S."xsd:string |
| http://purl.uniprot.org/citations/31746185 | http://purl.uniprot.org/core/author | "Kutateladze T.G."xsd:string |
| http://purl.uniprot.org/citations/31746185 | http://purl.uniprot.org/core/author | "Mondal P."xsd:string |
| http://purl.uniprot.org/citations/31746185 | http://purl.uniprot.org/core/author | "Das C."xsd:string |
| http://purl.uniprot.org/citations/31746185 | http://purl.uniprot.org/core/author | "Gadad S.S."xsd:string |
| http://purl.uniprot.org/citations/31746185 | http://purl.uniprot.org/core/author | "Tiwary N."xsd:string |
| http://purl.uniprot.org/citations/31746185 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31746185 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/31746185 | http://purl.uniprot.org/core/pages | "389-399"xsd:string |
| http://purl.uniprot.org/citations/31746185 | http://purl.uniprot.org/core/title | "TCF19 Promotes Cell Proliferation through Binding to the Histone H3K4me3 Mark."xsd:string |
| http://purl.uniprot.org/citations/31746185 | http://purl.uniprot.org/core/volume | "59"xsd:string |
| http://purl.uniprot.org/citations/31746185 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31746185 |
| http://purl.uniprot.org/citations/31746185 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31746185 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JIJ7-mappedCitation-31746185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31746185 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X8M7-mappedCitation-31746185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31746185 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X8N8-mappedCitation-31746185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31746185 |
| http://purl.uniprot.org/uniprot/#_D2IYK5-mappedCitation-31746185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31746185 |
| http://purl.uniprot.org/uniprot/#_Q9Y242-mappedCitation-31746185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31746185 |
| http://purl.uniprot.org/uniprot/A0A1U9X8M7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31746185 |
| http://purl.uniprot.org/uniprot/Q9Y242 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/31746185 |