| http://purl.uniprot.org/citations/31746486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31746486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31746486 | http://www.w3.org/2000/01/rdf-schema#comment | "The transport of N-methyl-d-aspartate receptors (NMDARs) is crucial for neuronal plasticity and synapse formation. Here, we show that KIF3B, a member of the kinesin superfamily proteins (KIFs), supports the transport of vesicles simultaneously containing NMDAR subunit 2A (NR2A) and the adenomatous polyposis coli (APC) complex. Kif3b+/- neurons exhibited a reduction in dendritic levels of both NR2A and NR2B due to the impaired transport of NR2A and increased degradation of NR2B. In Kif3b+/- hippocampal slices, electrophysiological NMDAR response was found decreased and synaptic plasticity was disrupted, which corresponded to a common feature of schizophrenia (SCZ). The histological features of Kif3b+/- mouse brain also mimicked SCZ features, and Kif3b+/- mice exhibited behavioral defects in prepulse inhibition (PPI), social interest, and cognitive flexibility. Indeed, a mutation of KIF3B was specifically identified in human SCZ patients, which was revealed to be functionally defective in a rescue experiment. Therefore, we propose that KIF3B transports NR2A/APC complex and that its dysfunction is responsible for SCZ pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.2018101090"xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.2018101090"xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/author | "Hirokawa N."xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/author | "Hirokawa N."xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/author | "Tanaka Y."xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/author | "Tanaka Y."xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/author | "Morikawa M."xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/author | "Morikawa M."xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/author | "Takei Y."xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/author | "Takei Y."xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/author | "Alsabban A.H."xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/author | "Alsabban A.H."xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/pages | "e101090"xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/pages | "e101090"xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/title | "Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice."xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/title | "Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice."xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/31746486 | http://purl.uniprot.org/core/volume | "39"xsd:string |