| http://purl.uniprot.org/citations/31746739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31746739 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell diversity of the brain and how it is affected by starvation, remains largely unknown. Here, we introduce a single cell transcriptome atlas of the entire Drosophila first instar larval brain. We first assigned cell-type identity based on known marker genes, distinguishing five major groups: neural progenitors, differentiated neurons, glia, undifferentiated neurons and non-neural cells. All major classes were further subdivided into multiple subtypes, revealing biological features of various cell-types. We further assessed transcriptional changes in response to starvation at the single-cell level. While after starvation the composition of the brain remains unaffected, transcriptional profile of several cell clusters changed. Intriguingly, different cell-types show very distinct responses to starvation, suggesting the presence of cell-specific programs for nutrition availability. Establishing a single-cell transcriptome atlas of the larval brain provides a powerful tool to explore cell diversity and assess genetic profiles from developmental, functional and behavioral perspectives."xsd:string |
| http://purl.uniprot.org/citations/31746739 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.50354"xsd:string |
| http://purl.uniprot.org/citations/31746739 | http://purl.uniprot.org/core/author | "Bruggmann R."xsd:string |
| http://purl.uniprot.org/citations/31746739 | http://purl.uniprot.org/core/author | "Sprecher S.G."xsd:string |
| http://purl.uniprot.org/citations/31746739 | http://purl.uniprot.org/core/author | "Brunet Avalos C."xsd:string |
| http://purl.uniprot.org/citations/31746739 | http://purl.uniprot.org/core/author | "Maier G.L."xsd:string |
| http://purl.uniprot.org/citations/31746739 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31746739 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/31746739 | http://purl.uniprot.org/core/pages | "e50354"xsd:string |
| http://purl.uniprot.org/citations/31746739 | http://purl.uniprot.org/core/title | "Single cell transcriptome atlas of the Drosophila larval brain."xsd:string |
| http://purl.uniprot.org/citations/31746739 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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