| http://purl.uniprot.org/citations/31748609 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31748609 | http://www.w3.org/2000/01/rdf-schema#comment | "Adamts16 encodes a disintegrin-like and metalloproteinase with thrombospondin motifs, 16, a member of a family of multi-domain, zinc-binding proteinases. ADAMTS-16 is implicated in a number of pathological conditions, including hypertension, cancer and osteoarthritis. A large number of observations, including a recent report of human ADAMTS16 variants in cases of 46,XY disorders/differences of sex development (DSD), also implicate this gene in human testis determination. We used CRISPR/Cas9 genome editing to generate a loss-of-function allele in the mouse in order to examine whether ADAMTS-16 functions in mouse testis determination or testicular function. Male mice lacking Adamts16 on the C57BL/6N background undergo normal testis determination in the fetal period. However, adult homozygotes have an average testis weight that is around 10% lower than age-matched controls. Cohorts of mutant males tested at 3-months and 6-months of age were fertile. We conclude that ADAMTS-16 is not required for testis determination or male fertility in mice. We discuss these phenotypic data and their significance for our understanding of ADAMTS-16 function."xsd:string |
| http://purl.uniprot.org/citations/31748609 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-019-53900-0"xsd:string |
| http://purl.uniprot.org/citations/31748609 | http://purl.uniprot.org/core/author | "Greenfield A."xsd:string |
| http://purl.uniprot.org/citations/31748609 | http://purl.uniprot.org/core/author | "Wells S."xsd:string |
| http://purl.uniprot.org/citations/31748609 | http://purl.uniprot.org/core/author | "Warr N."xsd:string |
| http://purl.uniprot.org/citations/31748609 | http://purl.uniprot.org/core/author | "Teboul L."xsd:string |
| http://purl.uniprot.org/citations/31748609 | http://purl.uniprot.org/core/author | "Siggers P."xsd:string |
| http://purl.uniprot.org/citations/31748609 | http://purl.uniprot.org/core/author | "Codner G."xsd:string |
| http://purl.uniprot.org/citations/31748609 | http://purl.uniprot.org/core/author | "Mianne J."xsd:string |
| http://purl.uniprot.org/citations/31748609 | http://purl.uniprot.org/core/author | "Chalon N."xsd:string |
| http://purl.uniprot.org/citations/31748609 | http://purl.uniprot.org/core/author | "Livermore C."xsd:string |
| http://purl.uniprot.org/citations/31748609 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31748609 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/31748609 | http://purl.uniprot.org/core/pages | "17195"xsd:string |
| http://purl.uniprot.org/citations/31748609 | http://purl.uniprot.org/core/title | "Male mice lacking ADAMTS-16 are fertile but exhibit testes of reduced weight."xsd:string |
| http://purl.uniprot.org/citations/31748609 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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