| http://purl.uniprot.org/citations/31754032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31754032 | http://www.w3.org/2000/01/rdf-schema#comment | "Inositol phosphates (IPs) comprise a network of phosphorylated molecules that play multiple signaling roles in eukaryotes. IPs synthesis is believed to originate with IP3 generated from PIP2 by phospholipase C (PLC). Here, we report that in mammalian cells PLC-generated IPs are rapidly recycled to inositol, and uncover the enzymology behind an alternative "soluble" route to synthesis of IPs. Inositol tetrakisphosphate 1-kinase 1 (ITPK1)-found in Asgard archaea, social amoeba, plants, and animals-phosphorylates I(3)P1 originating from glucose-6-phosphate, and I(1)P1 generated from sphingolipids, to enable synthesis of IP6 We also found using PAGE mass assay that metabolic blockage by phosphate starvation surprisingly increased IP6 levels in a ITPK1-dependent manner, establishing a route to IP6 controlled by cellular metabolic status, that is not detectable by traditional [3H]-inositol labeling. The presence of ITPK1 in archaeal clades thought to define eukaryogenesis indicates that IPs had functional roles before the appearance of the eukaryote."xsd:string |
| http://purl.uniprot.org/citations/31754032 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1911431116"xsd:string |
| http://purl.uniprot.org/citations/31754032 | http://purl.uniprot.org/core/author | "Miller G.J."xsd:string |
| http://purl.uniprot.org/citations/31754032 | http://purl.uniprot.org/core/author | "Saiardi A."xsd:string |
| http://purl.uniprot.org/citations/31754032 | http://purl.uniprot.org/core/author | "Desfougeres Y."xsd:string |
| http://purl.uniprot.org/citations/31754032 | http://purl.uniprot.org/core/author | "Laha D."xsd:string |
| http://purl.uniprot.org/citations/31754032 | http://purl.uniprot.org/core/author | "Wilson M.S.C."xsd:string |
| http://purl.uniprot.org/citations/31754032 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31754032 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/31754032 | http://purl.uniprot.org/core/pages | "24551-24561"xsd:string |
| http://purl.uniprot.org/citations/31754032 | http://purl.uniprot.org/core/title | "ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism."xsd:string |
| http://purl.uniprot.org/citations/31754032 | http://purl.uniprot.org/core/volume | "116"xsd:string |
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