| http://purl.uniprot.org/citations/31757956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/31757956 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA replication stress-mediated activation of the ATR kinase pathway is important for maintaining genomic stability. In this study, we identified a zinc finger protein, ZFP161 that functions as a replication stress response factor in ATR activation. Mechanistically, ZFP161 acts as a scaffolding protein to facilitate the interaction between RPA and ATR/ATRIP. ZFP161 binds to RPA and ATR/ATRIP through distinct regions and stabilizes the RPA-ATR-ATRIP complex at stalled replication forks. This function of ZFP161 is important to the ATR signaling cascade and genome stability maintenance. In addition, ZFP161 knockout mice showed a defect in ATR activation and genomic instability. Furthermore, low expression of ZFP161 is associated with higher cancer risk and chromosomal instability. Overall, these findings suggest that ZFP161 coordinates ATR/Chk1 pathway activation and helps maintain genomic stability."xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-019-13321-z"xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/author | "Deng M."xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/author | "Kim W."xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/author | "Qin S."xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/author | "Wu R."xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/author | "Zhou Q."xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/author | "Yuan J."xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/author | "Zhao F."xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/author | "Guo G."xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/author | "Lou Z."xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/author | "Nowsheen S."xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/author | "Luo K."xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/pages | "5304"xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/title | "ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex."xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/31757956 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/31757956 |
| http://purl.uniprot.org/citations/31757956 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/31757956 |
| http://purl.uniprot.org/uniprot/#_B2R850-mappedCitation-31757956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31757956 |
| http://purl.uniprot.org/uniprot/#_Q08376-mappedCitation-31757956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/31757956 |